Evidence map›Paper›PMID 38191649›Full record

ReviewCommunications biology2024

A revised nomenclature for the lemur family of protein kinases.

Gábor M Mórotz, Neil A Bradbury, Oana Caluseriu, Shin-Ichi Hisanaga, Christopher C J Miller, Agnieszka Swiatecka-Urban, Heinz-Josef Lenz, Stephen J Moss, Georgios Giamas

Open access · goldAbstract readReview
In one paragraph

Review in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Therapeutic advances of targeting receptor tyrosine kinases in cancer.Signal transduction and targeted therapy · 2024
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 9 institutions in 5 countries.

Gábor M MórotzDepartment of Pharmacology and Pharmacotherapy, Semmelweis University, 1089, Budapest, Hungary. morotz.gabor@semmelweis.hu.ORCID 0000-0003-4223-7009
Neil A Bradbury *Department of Physiology and Biophysics, Chicago Medical School, North Chicago, IL, 60064, USA.
Oana Caluseriu *Department of Medical Genetics, University of Alberta Hospital, Edmonton, AB, T6G 2H7, Canada.
Shin-Ichi Hisanaga *Laboratory of Molecular Neuroscience, Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Minami-Osawa, Hachioji, Tokyo, 92-0397, Japan.
Christopher C J Miller *Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9RX, UK.
Agnieszka Swiatecka-Urban *Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, 22903, USA.
Heinz-Josef Lenz *Department of Medicine, University of Southern California/Norris Comprehensive Cancer Centre, Los Angeles, CA, 90033, USA.ORCID 0000-0003-2178-9568
Stephen J Moss *Department of Neuroscience, Tufts University School of Medicine, Boston, MA, 02111, USA.
Georgios GiamasDepartment of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Brighton, BN1 9QG, UK. g.giamas@sussex.ac.uk.ORCID 0000-0002-4417-2707
Alberta Hospital Edmonton · CAKing's College London · GBRosalind Franklin University of Medicine and Science · USSemmelweis University · HUTokyo Metropolitan University · JPTufts University · USUniversity of Southern California · USUniversity of Sussex · GBUniversity of Virginia · US

Funding

Single-Cell Epigenomics, Transcriptomics, and Bioinformatics CoreP50DK096373 · NIDDK · UNIVERSITY OF VIRGINIA · PI ROBERTO Ariel GOMEZ · 2012 to 2026
$13.8M
Correcting Pathogenic TGF beta Activity in the AirwayR01HL144539 · NHLBI · UNIVERSITY OF VIRGINIA · PI SWIATECKA-URBAN, AGNIESZKA · 2019 to 2022
$1.7M
Medical Research Council MR/R022666/1NHLBI NIH HHS R01 HL144539NIDDK NIH HHS P50 DK096373
6 · The paper itself

Abstract

The lemur family of protein kinases has gained much interest in recent years as they are involved in a variety of cellular processes including regulation of axonal transport and endosomal trafficking, modulation of synaptic functions, memory and learning, and they are centrally placed in several intracellular signalling pathways. Numerous studies have also implicated role of the lemur kinases in the development and progression of a wide range of cancers, cystic fibrosis, and neurodegenerative diseases. However, parallel discoveries and inaccurate prediction of their kinase activity have resulted in a confusing and misleading nomenclature of these proteins. Herein, a group of international scientists with expertise in lemur family of protein kinases set forth a novel nomenclature to rectify this problem and ultimately help the scientific community by providing consistent information about these molecules.

Indexed as

Cystic FibrosisLemurAnimalsAxonal TransportPhosphorylationProtein KinasesProtein Kinases

Identifiers

PMID38191649
PMCPMC10774328
OpenAlexW4390669187

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.