Evidence map›Paper›PMID 38193679›Full record

ArticlemSphere2024

Distinct structural motifs are necessary for targeting and import of Tim17 in

Chauncey Darden, Joseph E Donkor, Olga Korolkova, Muhammad Younas Khan Barozai, Minu Chaudhuri

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. From the cytosol to the inner membrane: biogenesis of the mitochondrial carrier family.Protein science : a publication of the Protein Society · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Chauncey DardenDepartment of Biochemistry, Cancer Biology, Neuroscience, and Pharmacology, Meharry Medical College, Nashville, Tennessee, USA.
Joseph E DonkorDepartment of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, Tennessee, USA.
Olga KorolkovaThe Consolidated Research Instrumentation, Informatics, Statistics, and Learning Integration Suite (CRISALIS), Meharry Medical College, Nashville, Tennessee, USA.
Muhammad Younas Khan BarozaiCenter for AIDS Health Disparities Research, Meharry Medical College, Nashville, Tennessee, USA.
Minu ChaudhuriDepartment of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, Tennessee, USA.ORCID 0000-0001-7626-1280
Meharry Medical College · US

Funding

The RCMI Program in Health Disparities Research at Meharry Medical College - SupplementU54MD007586 · NIMHD · MEHARRY MEDICAL COLLEGE · PI SANIKA SAMUEL CHIRWA · 2017 to 2026
$48.2M
THE MEHARRY RISE INITIATIVER25GM059994 · NIGMS · MEHARRY MEDICAL COLLEGE · PI MOTLEY-JOHNSON, EVANGELINE D · 1999 to 2021
$23.0M
Translational Pathology CoreU54CA163069 · NCI · MEHARRY MEDICAL COLLEGE · PI ADUNYAH, SAMUEL EVANS, STEWART, LAMONICA VANETTE · 2011 to 2025
$18.8M
Meharry RCMI Program in Women's Health ResearchG12MD007586 · NIMHD · MEHARRY MEDICAL COLLEGE · PI HILDRETH, JAMES E · 2012 to 2016
$7.8M
Hypertension and Cardiorenal Research Training ProgramT32HL105324 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI Joey P. Granger · 2010 to 2026
$7.8M
Structure and function of the Trypanosome TIM complexR01AI125662 · NIAID · MEHARRY MEDICAL COLLEGE · PI CHAUDHURI, MINU · 2016 to 2020
$1.9M
Live Cell Imaging Confocal Microscope SystemS10RR025497 · NCRR · MEHARRY MEDICAL COLLEGE · PI GOODWIN, JEFFREY SHAWN · 2010 to 2010
$419k
NCI NIH HHS U54 CA163069NCRR NIH HHS S10 RR025497NHLBI NIH HHS T32 HL105324NIAID NIH HHS R01 AI125662NIGMS NIH HHS R25 GM059994NIMHD NIH HHS G12 MD007586NIMHD NIH HHS U54 MD007586
6 · The paper itself

Abstract

Nuclear-encoded mitochondrial proteins are correctly translocated to their proper sub-mitochondrial destination using location-specific mitochondrial targeting signals and via multi-protein import machineries (translocases) in the outer and inner mitochondrial membranes (TOM and TIMs, respectively). However, targeting signals of multi-pass Tims are less defined. Here, we report the characterization of the targeting signals of

Indexed as

Trypanosoma brucei bruceiAnimalsHumansMitochondriaMitochondrial MembranesMitochondrial ProteinsProtein TransportMitochondrial Proteinsmitochondriaprotein importtargeting signalTbTim17Trypanosoma brucei

Identifiers

PMID38193679
PMCPMC10871166
OpenAlexW4391109305

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.