Evidence map›Paper›PMID 38194447›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Control of cardiac contractions using Cre-lox and degron strategies in zebrafish.

Thomas Juan, Maëlle Bellec, Bárbara Cardoso, Héloïse Athéa, Nana Fukuda, Marga Albu, Stefan Günther, Mario Looso, Didier Y R Stainier

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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  8. Science advances · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Thomas JuanDepartment of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim 61231, Germany.
Maëlle Bellec *Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim 61231, Germany.ORCID 0000-0002-9029-0042
Bárbara Cardoso *Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim 61231, Germany.ORCID 0009-0003-6424-3175
Héloïse AthéaDepartment of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim 61231, Germany.ORCID 0000-0001-9536-6387
Nana FukudaDepartment of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim 61231, Germany.ORCID 0009-0001-8155-961X
Marga AlbuDepartment of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim 61231, Germany.ORCID 0009-0004-9409-8762
Stefan GüntherGerman Centre for Cardiovascular Research (Deutsches Zentrum für Herz- Kreislaufforschung), Bad Nauheim 61231, Germany.
Mario LoosoGerman Centre for Cardiovascular Research (Deutsches Zentrum für Herz- Kreislaufforschung), Bad Nauheim 61231, Germany.
Didier Y R StainierDepartment of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim 61231, Germany.ORCID 0000-0002-0382-0026
Max Planck Institute for Heart and Lung Research · DE

Funding

Deutsches Zentrum für Herz-Kreislaufforschung (DZHK) 81X3200310EC | European Research Council (ERC) AdG 101021349-TAaGCEuropean Molecular Biology Organization (EMBO) ALTF 1234-2018
6 · The paper itself

Abstract

Cardiac contractions and hemodynamic forces are essential for organ development and homeostasis. Control over cardiac contractions can be achieved pharmacologically or optogenetically. However, these approaches lack specificity or require direct access to the heart. Here, we compare two genetic approaches to control cardiac contractions by modulating the levels of the essential sarcomeric protein Tnnt2a in zebrafish. We first recombine a newly generated

Indexed as

PerciformesZebrafishAllelesAnimalsDegronsMyocytes, Cardiaccardiac contractionscardiac troponin TcpFRB2-FKBPCre-loxDegron

Identifiers

PMID38194447
PMCPMC10801847
OpenAlexW4390743449

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.