Evidence map›Paper›PMID 38197630›Full record

ArticleJournal of virology2024

Ceramide promotes lytic reactivation of Epstein-Barr virus in gastric carcinoma.

Jun Yeob Kim, Young Jin Min, Min-Hyeok Lee, Yea Rim An, Hassan Ashktorab, Duane T Smoot, Sung Won Kwon, Suk Kyeong Lee

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Viral oncogenesis in cancer: from mechanisms to therapeutics.Signal transduction and targeted therapy · 2025
    Review
  8. Article
  9. Review
  10. Dysregulated genes in HIGK-treatedMolecular biology research communications · 2025
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Jun Yeob KimDepartment of Medical Life Sciences, College of Medicine, The Catholic University of Korea, Seoul, South Korea.ORCID 0009-0008-5794-7875
Young Jin MinCollege of Pharmacy, Seoul National University, Seoul, South Korea.
Min-Hyeok LeeDepartment of Medical Life Sciences, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Yea Rim AnDepartment of Medical Life Sciences, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Hassan AshktorabDepartment of Medicine, Howard University, Washington, DC, USA.
Duane T SmootDepartment of Medicine, Howard University, Washington, DC, USA.
Sung Won KwonCollege of Pharmacy, Seoul National University, Seoul, South Korea.
Suk Kyeong LeeDepartment of Medical Life Sciences, College of Medicine, The Catholic University of Korea, Seoul, South Korea.ORCID 0000-0002-3751-7682
Catholic University of Korea · KRHoward University · USSeoul National University · KR

Funding

Institute for Basic Science (IBS) IBS-R801-D9-A06National Research Foundation of Korea (NRF) NRF-2020R1A6A3A13077231, NRF-2021R1A2C1006571
6 · The paper itself

Abstract

Epstein-Barr virus (EBV) has a lifelong latency period after initial infection. Rarely, however, when the EBV immediate early gene BZLF1 is expressed by a specific stimulus, the virus switches to the lytic cycle to produce progeny viruses. We found that EBV infection reduced levels of various ceramide species in gastric cancer cells. As ceramide is a bioactive lipid implicated in the infection of various viruses, we assessed the effect of ceramide on the EBV lytic cycle. Treatment with C

Indexed as

CarcinomaCeramidesEpstein-Barr Virus InfectionsStomach NeoplasmsCell Line, TumorHerpesvirus 4, HumanHost-Pathogen InteractionsHumansMitogen-Activated Protein Kinase 3Trans-ActivatorsVirus ActivationCeramidesMitogen-Activated Protein Kinase 3Trans-ActivatorsautophagyBZLF1ceramideCREBEpstein-Barr virusERK1/2gastric carcinomaglucosylceramidelytic replication

Identifiers

PMID38197630
PMCPMC10878077
OpenAlexW4390703543

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.