Evidence map›Paper›PMID 38197879›Full record

ArticleeLife2024

The Na

Tenzin Ngodup, Tomohiko Irie, Seán P Elkins, Laurence O Trussell

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. NaThe Journal of membrane biology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Tenzin Ngodup *Oregon Hearing Research Center and Vollum Institute, Oregon Health & Science University, Portland, United States.
Tomohiko Irie *Department of Physiology, Kitasato University School of Medicine, Sagamihara, Japan.
Seán P ElkinsOregon Hearing Research Center and Vollum Institute, Oregon Health & Science University, Portland, United States.
Laurence O TrussellOregon Hearing Research Center and Vollum Institute, Oregon Health & Science University, Portland, United States.ORCID https://orcid.org/0000-0003-1171-2356
Oregon Health & Science University · USKitasato University · JP

Funding

Synaptic mechanisms in the auditory system (Administrative Supplement)R01DC004450 · NIDCD · OREGON HEALTH & SCIENCE UNIVERSITY · PI LAURENCE O TRUSSELL · 1999 to 2026
$10.6M
Regulation of axonal and synaptic signaling in interneuron (supplement)R35NS116798 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI LAURENCE O TRUSSELL · 2020 to 2026
$4.1M
NIDCD NIH HHS DC004450NIDCD NIH HHS R01 DC004450NINDS NIH HHS R35 NS116798NINDS NIH HHS R35NS116798
6 · The paper itself

Abstract

Cartwheel interneurons of the dorsal cochlear nucleus (DCN) potently suppress multisensory signals that converge with primary auditory afferent input, and thus regulate auditory processing. Noradrenergic fibers from locus coeruleus project to the DCN, and α2-adrenergic receptors inhibit spontaneous spike activity but simultaneously enhance synaptic strength in cartwheel cells, a dual effect leading to enhanced signal-to-noise for inhibition. However, the ionic mechanism of this striking modulation is unknown. We generated a glycinergic neuron-specific knockout of the Na

Indexed as

InterneuronsNeuronsAnimalsAuditory PerceptionIon ChannelsIonsMembrane ProteinsMiceReceptors, AdrenergicReceptors, GABA-BIon ChannelsIonsMembrane ProteinsNALCN protein, mouseReceptors, AdrenergicReceptors, GABA-BadrenergicauditoryGPCRinhibitioninterneuronmouseneuroscience

Identifiers

PMID38197879
PMCPMC10945507
OpenAlexW4385255236

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.