ArticleScience advances2024
Molecular profiling of human substantia nigra identifies diverse neuron types associated with vulnerability in Parkinson's disease.
Open access · goldAbstract read
In one paragraph
Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
13.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Improving reproducibility of differentially expressed genes in single-cell transcriptomic studies of neurodegenerative diseases through meta-analysis.Nature communications · 2025Pooled it
- Peripheral blood DNA methylation partially reports on immune cell type composition in the frontal brain.Brain, behavior, & immunity - health · 2026Article
- PLXDC2 siRNA-Mediated Intervention Attenuates Microglial Senescence Through cGAS-STING Signaling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Single-cell transcriptomics of human brain disorders.Molecular psychiatry · 2026Review
- Selective Neuronal Vulnerability to Alpha-Synuclein Pathology in Parkinson's Disease: A Critical Review of Mechanistic Rationale and Biomarker Stratification.Medical sciences (Basel, Switzerland) · 2026Review
- Nigrostriatal dopaminergic vulnerability in Parkinson's disease: Neuroprotective strategies.Neural regeneration research · 2026Article
- Advances in sex-specific single-cell transcriptomic profiling in Parkinson's disease.Journal of Parkinson's disease · 2026Review
- Article
- Single nuclear RNA sequencing shows altered microglial and astrocytic functions in post-mortem Parkinson's disease tissue.BMC genomic data · 2026Article
- Advances and applications of brain organoids in central nervous system disorders: Bridging the gap from laboratory to clinic.Neural regeneration research · 2026Article
- PINK1 loss in astrocytes triggers inflammatory dysfunction and neuronal death.bioRxiv : the preprint server for biology · 2026Article
- Charting the human-specific properties of gene expression networks in the infant prefrontal cortex.Science advances · 2026Article
- Iron accumulation in the substantia nigra is linked to functional network connectivity alterations in early-stage Parkinson's Disease: an exploratory study.NPJ Parkinson's disease · 2026Article
- Photonic and nanomaterial-driven optical biosensing strategies for Parkinson's disease.Mikrochimica acta · 2026Review
- Single-nucleus brain transcriptomics reveals microglia dysfunction in multiple system atrophy.Nature communications · 2026Article
- Single-nucleus multiomic profiling of the aging mouse substantia nigra reveals conserved gene alterations linked to Parkinson's disease.Genome research · 2026Article
- Downregulated transcription in chromosomal domains of midbrain dopamine neurons linked to schizophrenia.Nature communications · 2026Article
- Parkinson's Disease: From Metabolism to Genetics-A Comprehensive Review.Current issues in molecular biology · 2026Review
- Single-cell transcriptomics revealed molecular vulnerability in a human midbrain-like organoid model of Parkinson's disease.iScience · 2026Article
- Testing an inverse link between limbic alpha-synucleinopathy and myelin markers in mice and humans.NPJ Parkinson's disease · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 5 institutions in 2 countries.
Qian WangDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.ORCID 0000-0001-5504-0008
Minghui WangDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.ORCID 0000-0001-9171-4962
Insup ChoiDepartment of Neurology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.ORCID 0000-0001-8314-8067
Lily SarrafhaDepartment of Neurology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.ORCID 0000-0002-6168-2119
Marianna LiangDepartment of Neurology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.ORCID 0000-0001-6702-3256
Lap HoDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.ORCID 0000-0002-1895-2398
Kurt FarrellNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, NY 10029, USA.ORCID 0000-0001-6955-7278
Kristin G BeaumontDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.ORCID 0000-0003-3075-9977
Robert SebraDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.
Claudia De SanctisNeuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, NY 10029, USA.ORCID 0000-0002-9318-7323
John F CraryNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, NY 10029, USA.
Tim AhfeldtNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, NY 10029, USA.ORCID 0000-0001-6377-7376
Joel BlanchardNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, NY 10029, USA.ORCID 0000-0003-3142-2970
Drew NeavinGarvan-Weizmann Centre for Cellular Genomics, Garvan Institute for Medical Research, 384 Victoria Street, Sydney 2010, Australia.ORCID 0000-0002-1783-6491
Joseph PowellGarvan-Weizmann Centre for Cellular Genomics, Garvan Institute for Medical Research, 384 Victoria Street, Sydney 2010, Australia.ORCID 0000-0002-5070-4124
David A DavisDepartment of Neurology, Evelyn F. McKnight Brain Institute, Brain Endowment Bank, University of Miami Miller School of Medicine, Miami, FL 33136, USA.ORCID 0000-0002-9323-6180
Xiaoyan SunDepartment of Neurology, Evelyn F. McKnight Brain Institute, Brain Endowment Bank, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Bin ZhangDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.ORCID 0000-0002-9549-5653
Zhenyu YueDepartment of Neurology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.ORCID 0000-0001-8730-8515
Allen Institute for Brain Science · USIcahn School of Medicine at Mount Sinai · USGarvan Institute of Medical Research · AUUniversity of Miami · USSema4 (United States) · US
Funding
Integrative Network Biology Approaches to Identify, Characterize and Validate Molecular Subtypes in Alzheimer's DiseaseU01AG046170 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WANG, MINGHUI, ZHANG, BIN · 2013 to 2022
$26.0MNeuronal Autophagy: a Cell-Autonomous Protection MechanismR01NS060123 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Zhenyu Yue · 2008 to 2026
$9.2MClinical Pathological Study of Cognitive Impairment in Essential TremorR01NS086736 · NINDS · YALE UNIVERSITY · PI COSENTINO, STEPHANIE ANN, LOUIS, ELAN D · 2014 to 2023
$8.1MDetermining the neuroprotective mechanism for microglial autophagy in Alzheimer's diseaseR01AG072520 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI YUE, ZHENYU · 2021 to 2025
$4.2MRegulation of tau expression in Alzheimer disease and agingR01AG054008 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CRARY, JOHN FONDA · 2016 to 2020
$4.0MTraining Program in NeuroscienceT32MH087004 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GEORGE W. HUNTLEY · 2009 to 2026
$4.0MMechanisms of Age-Related TauopathyR01NS095252 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI John Fonda Crary · 2015 to 2026
$3.4MResearch Training in the Neuroscience of AgingT32AG049688 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Joseph Michael Castellano, PATRICK R HOF · 2015 to 2026
$3.0MUnderstanding Cell-type Vulnerability and Oxidative Stress Pathology in Parkinson's Disease Using Isogenic Human Dopaminergic NeuronsR01NS114239 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BLANCHARD, JOEL WILLIAM · 2020 to 2024
$2.2MMolecular and Cellular Basis of the Gut-Brain Axis in Parkinsons DiseaseP20NS123220 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI PETER, INGA · 2021 to 2022
$1.0MNovel artificial intelligence-based approaches to understand the pathological and genetic drivers of primary tauopathiesK01AG070326 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FARRELL, KURT WILLIAM · 2022 to 2025
$503kRoles of Autophagy in Microglial Senescence and Parkinsons DiseaseK01AG078442 · NIA · NORTHWESTERN UNIVERSITY · PI Insup Choi · 2023 to 2026
$503kMedical Research CouncilNIA NIH HHS K01 AG070326NIA NIH HHS K01 AG078442NIA NIH HHS R01 AG054008NIA NIH HHS R01 AG072520NIA NIH HHS T32 AG049688NIA NIH HHS U01 AG046170NIMH NIH HHS T32 MH087004NINDS NIH HHS P20 NS123220NINDS NIH HHS R01 NS060123NINDS NIH HHS R01 NS086736NINDS NIH HHS R01 NS095252NINDS NIH HHS R01 NS114239NINDS NIH HHS R21 NS109895
Abstract
Parkinson's disease (PD) is characterized pathologically by the loss of dopaminergic (DA) neurons in the substantia nigra (SN). Whether cell types beyond DA neurons in the SN show vulnerability in PD remains unclear. Through transcriptomic profiling of 315,867 high-quality single nuclei in the SN from individuals with and without PD, we identified cell clusters representing various neuron types, glia, endothelial cells, pericytes, fibroblasts, and T cells and investigated cell type-dependent alterations in gene expression in PD. Notably, a unique neuron cluster marked by the expression of
Indexed as
Endothelial CellsParkinson DiseaseAnimalsDopaminergic NeuronsHumansMiceNeurogliaSubstantia Nigra
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.