Evidence mapPaperPMID 38198570Full record

ReviewScience translational medicine2024

Prospective study design and data analysis in UK Biobank.

Naomi E Allen, Ben Lacey, Deborah A Lawlor, Jill P Pell, John Gallacher, Liam Smeeth, Paul Elliott, Paul M Matthews, Ronan A Lyons, Anthony D Whetton and 15 more

Abstract readReview
In one paragraph

Review in Science translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 148 papers.

0numbers the graph read from it
0cells of the map it votes in
148citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

148 citing papers in PubMed.

  1. Trial
  2. Article
  3. Associations Between Domestic Water Hardness, Genetic Risk and Severe MASLD: A Large-Scale Cohort Study.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review

88 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Naomi E AllenUK Biobank Ltd, Stockport, UK.ORCID 0000-0003-1938-5038
Ben LaceyUK Biobank Ltd, Stockport, UK.ORCID 0000-0003-0139-2934
Deborah A LawlorPopulation Health Science, Bristol Medical School University of Bristol, Bristol, UK.
Jill P PellSchool of Health and Wellbeing, University of Glasgow, Scotland.
John GallacherDepartment of Psychiatry, University of Oxford, Oxford, UK.ORCID 0000-0002-2394-5299
Liam SmeethLondon School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0002-9168-6022
Paul ElliottMRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.ORCID 0000-0002-7511-5684
Paul M MatthewsUK Dementia Research Centre Institute and Department of Brain Sciences, Imperial College London, London, UK.ORCID 0000-0002-1619-8328
Ronan A LyonsPopulation Data Science, Swansea University Medical School, Swansea, Wales.ORCID 0000-0001-5225-000X
Anthony D WhettonVeterinary Health Innovation Engine, University of Surrey, Guildford, UK.ORCID 0000-0002-1098-3878
Anneke LucassenNuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0003-3324-4338
Matthew E HurlesWellcome Trust Sanger Institute, Wellcome Genome Campus, Cambridge, UK.ORCID 0000-0002-2333-7015
Michael ChapmanNHS England, London, UK.ORCID 0000-0002-4582-6303
Andrew W RoddamOur Future Health, London, UK.
Natalie K FitzpatrickInstitute of Health Informatics, University College London, London, UK.ORCID 0000-0001-5000-2520
Anna L HansellCentre for Environmental Health and Sustainability, University of Leicester, Leicester, UK.ORCID 0000-0001-9904-7447
Rebecca HardySchool of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.ORCID 0000-0001-9949-0799
Riccardo E MarioniCentre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, Scotland.ORCID 0000-0003-4430-4260
Valerie B O'DonnellSchool of Medicine, Cardiff University, Cardiff, Wales.ORCID 0000-0003-4089-8460
Julie WilliamsUK Dementia Research Institute, Cardiff University, Cardiff, Wales.ORCID 0000-0002-4069-0259
Cecilia M LindgrenBig Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.
Mark EffinghamUK Biobank Ltd, Stockport, UK.ORCID 0000-0003-0174-4717
Jonathan SellorsUK Biobank Ltd, Stockport, UK.ORCID 0000-0002-4863-0605
John DaneshBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Rory CollinsUK Biobank Ltd, Stockport, UK.ORCID 0000-0001-8288-8602

Funding

The Massachusetts General Hospital Harvard Center for Reproductive MedicineP50HD104224 · MASSACHUSETTS GENERAL HOSPITAL · 2025 to 2025
$1.5M
Cancer Research UK 29017Medical Research Council MR/L010305/1NICHD NIH HHS P50 HD104224Wellcome Trust
6 · The paper itself

Abstract

Population-based prospective studies, such as UK Biobank, are valuable for generating and testing hypotheses about the potential causes of human disease. We describe how UK Biobank's study design, data access policies, and approaches to statistical analysis can help to minimize error and improve the interpretability of research findings, with implications for other population-based prospective studies being established worldwide.

Indexed as

Biological Specimen BanksUK BiobankData AnalysisHumansProspective StudiesResearch Design

Identifiers

PMID38198570
PMCPMC11127744

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.