SynthesisScience translational medicine2024
Allele-specific control of rodent and human lncRNA KMT2E-AS1 promotes hypoxic endothelial pathology in pulmonary hypertension.
Open access · greenAbstract readMeta-Analysis
In one paragraph
Synthesis in Science translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 20 citations in OpenAlex.
- Secretory Carrier Membrane Protein 3 Knockdown Attenuates Hypoxic Pulmonary Hypertension Potentially Involving WW Domain-Containing E3 Ubiquitin Protein Ligase 1.Biochemical genetics · 2026Article
- Pulmonary Hypertension Molecular Switch: HIF Signaling Pathway.Pulmonary circulation · 2026Review
- Snhg18 promotes hypoxic pulmonary hypertension by enhancing glycolysis.Respiratory research · 2026Article
- Broiler Ascites Syndrome as a Potential Spontaneous Animal Model for Human Pulmonary Arterial Hypertension: A Narrative Review.Life (Basel, Switzerland) · 2026Review
- Long Non-Coding RNA MALAT1 Regulates HMOX1 in Sickle Cell Disease-Associated Pulmonary Hypertension.Cells · 2026Article
- Targeting Endothelial KDM5A to Attenuate Aging and Ameliorate Age-Associated Metabolic Abnormalities.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Multifaceted mechanisms of plant metabolites in pulmonary arterial hypertension: a critical review beyond vasodilation.Frontiers in pharmacology · 2026Review
- NF-κB signaling as a critical inflammatory node in pulmonary arterial hypertension: from vascular remodeling to right heart failure.Frontiers in immunology · 2026Review
- Knockdown of the Long Noncoding RNA ZEB1-AS1 Accelerates Cardiac Hypertrophy via the miR-186-5p/HDAC2 Pathway.Arquivos brasileiros de cardiologia · 2025Article
- A novel sequence-based transformer model architecture for integrating multi-omics data in preterm birth risk prediction.NPJ digital medicine · 2025Article
- LncRNA-536 and RNA-Binding Protein RBM25 Interactions in Pulmonary Artery Smooth Muscle Cells: Implications in Pulmonary Hypertension.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Therapeutic targets for pulmonary arterial hypertension: insights into the emerging landscape.Expert opinion on therapeutic targets · 2025Review
- Review
- Natural products targeting the immune-metabolic regulatory network in pulmonary hypertension: mechanisms, classification, and therapeutic prospects.Frontiers in pharmacology · 2025Review
- A HIF-2α-dependentAnnals of translational medicine · 2024Article
- Treatability of the KMT2-Associated Neurodevelopmental Disorders Using Antisense Oligonucleotide-Based Treatments.Human mutation · 2024Review
- Unraveling the role of HIF and epigenetic regulation in pulmonary arterial hypertension: implications for clinical research and its therapeutic approach.Frontiers in medicine · 2024Review
Corrections and comments
- Commented on by
Authors and funding
52 authors at 20 institutions in 4 countries.
Yi-Yin TaiCenter for Pulmonary Vascular Biology and Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.ORCID 0000-0003-3674-0783
Qiujun YuCardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-0690-138X
Ying TangCenter for Pulmonary Vascular Biology and Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
Wei SunCenter for Pulmonary Vascular Biology and Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.ORCID 0000-0002-5255-1213
Neil J KellyCenter for Pulmonary Vascular Biology and Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.ORCID 0000-0003-0455-5348
Satoshi OkawaPittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
Jingsi ZhaoCenter for Pulmonary Vascular Biology and Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
Tae-Hwi Schwantes-AnDivision of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-6387-0095
Caroline LacouxUniversité Côte d'Azur, CNRS, IPMC, IHU RespiERA, Sophia-Antipolis, 06903, France.ORCID 0000-0002-1269-7306
Stephanie TorrinoUniversité Côte d'Azur, CNRS, IPMC, IHU RespiERA, Sophia-Antipolis, 06903, France.ORCID 0000-0002-8280-5907
Yassmin Al AarajCenter for Pulmonary Vascular Biology and Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.ORCID 0000-0002-3252-8606
Wadih El KhouryCenter for Pulmonary Vascular Biology and Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.ORCID 0000-0001-5635-9643
Vinny NegiCenter for Pulmonary Vascular Biology and Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
Mingjun LiuPittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
Catherine G CoreyPittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
Frances BelmontePittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
Sara O VargasDepartment of Pathology, Boston Children's Hospital, Boston, MA 02115, USA.
Brian SchwartzCamp4 Therapeutics, Cambridge, MA 02139, USA.ORCID 0000-0002-4659-9800
Bal BhatTranslate Bio, Lexington, MA 02421, USA.
B Nelson ChauOrna Therapeutics, Cambridge, MA 02139, USA.
Jason H KarnesDivision of Pharmacogenomics, College of Pharmacy, University of Arizona College of Medicine, Tucson, AZ 85721, USA.ORCID 0000-0001-5001-3334
Taijyu SatohCenter for Pulmonary Vascular Biology and Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.ORCID 0000-0002-1795-6872
Robert J BarndtCenter for Pulmonary Vascular Biology and Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.ORCID 0009-0001-6158-5415
Haodi WuCenter for Pulmonary Vascular Biology and Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.ORCID 0000-0002-7900-3073
Victoria N ParikhStanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jianrong WangDepartment of Computational Mathematics, Science, and Engineering, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0002-9290-4888
Yingze ZhangPittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.ORCID 0000-0001-6947-2901
Dennis McNamaraDivision of Cardiology, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.ORCID 0000-0003-3215-6504
Gang LiPittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.ORCID 0000-0003-1725-6611
Gil SpeyerResearch Computing, Arizona State University, Tempe, AZ 85281, USA.ORCID 0000-0001-5888-5209
Bing WangDepartment of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.ORCID 0000-0002-5185-3500
Sruti ShivaPittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.ORCID 0000-0003-3535-2113
Brett KaufmanPittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.ORCID 0000-0003-4767-4937
Seungchan KimCenter for Computational Systems Biology, Department of Electrical and Computer Engineering, Roy G. Perry College of Engineering, Prairie View A&M University, Prairie View, TX 77446, USA.ORCID 0000-0003-4183-4338
Delphine GomezPittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.ORCID 0000-0002-3880-6961
Bernard MariDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-0422-9182
Michael H ChoChanning Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-4907-1657
Adel BoueizChanning Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-1638-8575
Michael W PauciuloORCID 0000-0002-2141-2966
Laura SouthgateDepartment of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, King's College London, London, WC2R 2LS, UK.ORCID 0000-0002-2090-1450
Richard C TrembathDepartment of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, King's College London, London, WC2R 2LS, UK.ORCID 0000-0003-0550-3400
Olivier SitbonUniversité Paris-Saclay, INSERM, Assistance Publique Hôpitaux de Paris, Service de Pneumologie et Soins Intensifs Respiratoires, Hôpital Bicêtre, Le Kremlin Bicêtre, 94270, France.ORCID 0000-0002-1942-1951
Marc HumbertUniversité Paris-Saclay, INSERM, Assistance Publique Hôpitaux de Paris, Service de Pneumologie et Soins Intensifs Respiratoires, Hôpital Bicêtre, Le Kremlin Bicêtre, 94270, France.ORCID 0000-0003-0703-2892
Stefan GrafDepartment of Medicine, University of Cambridge, Cambridge, CB2 1TN, UK.ORCID 0000-0002-1315-8873
Nicholas W MorrellDepartment of Medicine, University of Cambridge, Cambridge, CB2 1TN, UK.ORCID 0000-0001-5700-9792
Christopher J RhodesNational Heart and Lung Institute, Imperial College London, London, SW3 6LY, UK.ORCID 0000-0002-4962-3204
Martin R WilkinsNational Heart and Lung Institute, Imperial College London, London, SW3 6LY, UK.ORCID 0000-0003-3926-1171
Mehdi NouraieCenter for Pulmonary Vascular Biology and Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.ORCID 0000-0001-7465-0581
William C NicholsCincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Ankit A DesaiDivision of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Thomas BerteroUniversité Côte d'Azur, CNRS, IPMC, IHU RespiERA, Sophia-Antipolis, 06903, France.ORCID 0000-0002-4801-9902
Stephen Y ChanCenter for Pulmonary Vascular Biology and Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.ORCID 0000-0002-9520-7527
University of Pittsburgh · USCentre National de la Recherche Scientifique · FRIndiana University School of MedicineBrigham and Women's Hospital · USImperial College London · GBInserm · FRKing's College London · GBUniversity of Pittsburgh Medical Center · USArizona State University · USBoston Children's Hospital · USC4 Therapeutics (United States) · USCincinnati Children's Hospital Medical Center · USMichigan State University · USNHS Blood and Transplant · GBPrairie View A&M University · USRaNA Therapeutics (United States) · USStanford Medicine · USSt George's, University of London · GBTranslate Bio (United States) · USUniversity of Arizona · US
Funding
Technology to Empower Changes in Health (TECH) Network Participant Technologies CenterU24OD023176 · OD · SCRIPPS RESEARCH INSTITUTE, THE · PI TOPOL, ERIC JEFFREY · 2016 to 2022
$204.7MPrecision Medicine Initiative Cohort Program BiobankU24OD023121 · OD · MAYO CLINIC ROCHESTER · PI CEKANOVA, MARIA, CICEK, MINE · 2016 to 2024
$185.5MAdaptive Platform for Personalized EngagementU24OD023163 · OD · VIGNET, INC. · PI JAIN, PRADUMAN · 2017 to 2020
$102.6MUniversity of Arizona-Banner Health All of Us Research Program OT2OD026549 · OD · UNIVERSITY OF ARIZONA · PI MORENO, FRANCISCO A, REIMAN, ERIC MICHAEL · 2018 to 2023
$78.9MCalifornia Precision Medicine Research Program ConsortiumOT2OD026552 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANTON-CULVER, HODA A, OHNO-MACHADO, LUCILA · 2018 to 2023
$73.4MAll of Us PennsylvaniaOT2OD026554 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E, VISWESWARAN, SHYAM · 2018 to 2023
$72.1MNew York City Consortium for Precision MedicineOT2OD026556 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BIER, LOUISE E, GHARAVI, ALI G · 2018 to 2023
$67.3MSouthEast Enrollment Center (SEEC) OT2OD026551 · OD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CARRASQUILLO, OLVEEN, COLON, VIVIAN · 2018 to 2023
$62.8MSouthern All of Us NetworkOT2OD026548 · OD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FOUAD, MONA N., KORF, BRUCE R · 2018 to 2023
$60.5MIllinois Precision Medicine Consortium OT2OD026557 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI AHSAN, HABIBUL, ARGOS, MARIA · 2018 to 2023
$60.5MThe New England Precision Medicine Consortium of the All of Us Research ProgramOT2OD026553 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CLARK, CHERYL RENEE, KARLSON, ELIZABETH W · 2018 to 2023
$58.8MTrans-America Consortium of the Health Care Systems Research Network for the All of Us Research ProgramOT2OD026550 · OD · HENRY FORD HEALTH SYSTEM · PI AHMEDANI, BRIAN KENNETH, JOHNSON, CHRISTINE C · 2018 to 2022
$57.3MBritish Heart Foundation FS/SBSRF/22/31025Medical Research Council MR/K020919/1NHLBI NIH HHS K08 HL141601NHLBI NIH HHS K08 HL143185NHLBI NIH HHS K99 HL133473NHLBI NIH HHS R00 HL133473NHLBI NIH HHS R01 HL089856NHLBI NIH HHS R01 HL122596NHLBI NIH HHS R01 HL124021NHLBI NIH HHS R01 HL137927NHLBI NIH HHS R01 HL147148NHLBI NIH HHS R01 HL151228NHLBI NIH HHS R01 HL160941NHLBI NIH HHS R24 HL105333NHLBI NIH HHS T32 HL129964NHLBI NIH HHS U01 HL089856NIH HHS OT2 OD023205NIH HHS OT2 OD023206NIH HHS OT2 OD025276NIH HHS OT2 OD025277NIH HHS OT2 OD025315NIH HHS OT2 OD025337NIH HHS OT2 OD026548NIH HHS OT2 OD026549NIH HHS OT2 OD026550NIH HHS OT2 OD026551NIH HHS OT2 OD026552NIH HHS OT2 OD026553NIH HHS OT2 OD026554NIH HHS OT2 OD026555NIH HHS OT2 OD026556NIH HHS OT2 OD026557NIH HHS S10 OD023684NIH HHS U24 OD023121NIH HHS U24 OD023163NIH HHS U24 OD023176
Abstract
Hypoxic reprogramming of vasculature relies on genetic, epigenetic, and metabolic circuitry, but the control points are unknown. In pulmonary arterial hypertension (PAH), a disease driven by hypoxia inducible factor (HIF)-dependent vascular dysfunction, HIF-2α promoted expression of neighboring genes, long noncoding RNA (lncRNA) histone lysine
Indexed as
Hypertension, PulmonaryRNA, Long NoncodingAllelesAnimalsBasic Helix-Loop-Helix ProteinsFamilial Primary Pulmonary HypertensionHistonesHumansHypoxiaLysineMethyltransferasesMiceRatsRodentiaBasic Helix-Loop-Helix ProteinsHistonesLysineMethyltransferasesRNA, Long Noncoding
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.