Evidence map›Paper›PMID 38200805›Full record

ArticleAnimals : an open access journal from MDPI2023

A Zebrafish Mutant in the Extracellular Matrix Protein Gene

Ratish Raman, Mohamed Ali Bahri, Christian Degueldre, Caroline Caetano da Silva, Christelle Sanchez, Agnes Ostertag, Corinne Collet, Martine Cohen-Solal, Alain Plenevaux, Yves Henrotin and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Ratish RamanLaboratory for Organogenesis and Regeneration (LOR), GIGA Institute, University of Liège, 4000 Liège, Belgium.ORCID 0000-0002-2187-9216
Mohamed Ali BahriGIGA CRC In Vivo Imaging, University of Liege, Sart Tilman, 4000 Liège, Belgium.
Christian DegueldreGIGA CRC In Vivo Imaging, University of Liege, Sart Tilman, 4000 Liège, Belgium.ORCID 0000-0002-9058-4390
Caroline Caetano da SilvaHospital Lariboisière, Reference Centre for Rare Bone Diseases, INSERM U1132, Université de Paris-Cité, F-75010 Paris, France.
Christelle SanchezMusculoSKeletal Innovative Research Lab, Center for Interdisciplinary Research on Medicines, University of Liège, 4000 Liège, Belgium.ORCID 0000-0002-1005-8172
Agnes OstertagHospital Lariboisière, Reference Centre for Rare Bone Diseases, INSERM U1132, Université de Paris-Cité, F-75010 Paris, France.ORCID 0000-0002-1966-3213
Corinne ColletHospital Lariboisière, Reference Centre for Rare Bone Diseases, INSERM U1132, Université de Paris-Cité, F-75010 Paris, France.
Martine Cohen-SolalHospital Lariboisière, Reference Centre for Rare Bone Diseases, INSERM U1132, Université de Paris-Cité, F-75010 Paris, France.ORCID 0000-0002-8582-8258
Alain PlenevauxGIGA CRC In Vivo Imaging, University of Liege, Sart Tilman, 4000 Liège, Belgium.ORCID 0000-0003-3011-4984
Yves HenrotinMusculoSKeletal Innovative Research Lab, Center for Interdisciplinary Research on Medicines, University of Liège, 4000 Liège, Belgium.
Marc MullerLaboratory for Organogenesis and Regeneration (LOR), GIGA Institute, University of Liège, 4000 Liège, Belgium.ORCID 0000-0001-6030-2164
University of Liège · BEInserm · FR

Funding

European Union MSCA-ITN project BioMedAqu GA 766347
6 · The paper itself

Abstract

Osteoarthritis is a degenerative articular disease affecting mainly aging animals and people. The extracellular matrix protein Efemp1 was previously shown to have higher turn-over and increased secretion in the blood serum, urine, and subchondral bone of knee joints in osteoarthritic patients. Here, we use the zebrafish as a model system to investigate the function of Efemp1 in vertebrate skeletal development and homeostasis. Using in situ hybridization, we show that the

Indexed as

ECMefemp1notochordosteoarthritisskeletal developmentvertebrazebrafish

Identifiers

PMID38200805
PMCPMC10778253
OpenAlexW4390174492

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.