Evidence map›Paper›PMID 38201484›Full record

ReviewCancers2023

Understanding the Genetic Landscape of Pancreatic Ductal Adenocarcinoma to Support Personalized Medicine: A Systematic Review.

Antonino Pantaleo, Giovanna Forte, Candida Fasano, Martina Lepore Signorile, Paola Sanese, Katia De Marco, Elisabetta Di Nicola, Marialaura Latrofa, Valentina Grossi, Vittoria Disciglio and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Antonino PantaleoMedical Genetics, National Institute of Gastroenterology-IRCCS "Saverio de Bellis" Research Hospital, 70013 Bari, Italy.ORCID 0000-0001-9260-8109
Giovanna ForteMedical Genetics, National Institute of Gastroenterology-IRCCS "Saverio de Bellis" Research Hospital, 70013 Bari, Italy.
Candida FasanoMedical Genetics, National Institute of Gastroenterology-IRCCS "Saverio de Bellis" Research Hospital, 70013 Bari, Italy.ORCID 0000-0001-5878-3480
Martina Lepore SignorileMedical Genetics, National Institute of Gastroenterology-IRCCS "Saverio de Bellis" Research Hospital, 70013 Bari, Italy.
Paola SaneseMedical Genetics, National Institute of Gastroenterology-IRCCS "Saverio de Bellis" Research Hospital, 70013 Bari, Italy.
Katia De MarcoMedical Genetics, National Institute of Gastroenterology-IRCCS "Saverio de Bellis" Research Hospital, 70013 Bari, Italy.
Elisabetta Di NicolaMedical Genetics, National Institute of Gastroenterology-IRCCS "Saverio de Bellis" Research Hospital, 70013 Bari, Italy.
Marialaura LatrofaMedical Genetics, National Institute of Gastroenterology-IRCCS "Saverio de Bellis" Research Hospital, 70013 Bari, Italy.
Valentina GrossiMedical Genetics, National Institute of Gastroenterology-IRCCS "Saverio de Bellis" Research Hospital, 70013 Bari, Italy.
Vittoria DisciglioMedical Genetics, National Institute of Gastroenterology-IRCCS "Saverio de Bellis" Research Hospital, 70013 Bari, Italy.
Cristiano SimoneMedical Genetics, National Institute of Gastroenterology-IRCCS "Saverio de Bellis" Research Hospital, 70013 Bari, Italy.
Gastroenterology Hospital "Saverio de Bellis" · IT

Funding

Italian Association for Cancer Research AIRC Felloship for Italy ID 26678-2021 to Martina Lepore SignorileItalian Association for Cancer Research IG-23794 2020-2024 to Cristiano SimoneItalian Ministry of Health Ricerca Corrente 2021-2023 to Cristiano SimoneItalian Ministry of Health Ricerca Corrente 2022-2024 to Candida FasanoItalian Ministry of Health Ricerca Corrente 2022-2024 to Vittoria DisciglioItalian Ministry of Health Ricerca Corrente 2023-2025 to Valentina GrossiItalian Ministry of Health Starting Grant SG-2019-12371540 to Paola Sanese
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal malignancies worldwide. While population-wide screening recommendations for PDAC in asymptomatic individuals are not achievable due to its relatively low incidence, pancreatic cancer surveillance programs are recommended for patients with germline causative variants in PDAC susceptibility genes or a strong family history. In this study, we sought to determine the prevalence and significance of germline alterations in major genes (

Indexed as

genetic risk assessmentgermline variantpancreatic adenocarcinomapersonalized medicine

Identifiers

PMID38201484
PMCPMC10778202
OpenAlexW4390061291

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.