Evidence map›Paper›PMID 38201520›Full record

ArticleCancers2023

Validation of Inflammatory Prognostic Biomarkers in Pleural Mesothelioma.

Stephanie Iser, Sarah Hintermair, Alexander Varga, Ali Çelik, Muhammet Sayan, Aykut Kankoç, Nalan Akyürek, Betül Öğüt, Pietro Bertoglio, Enrico Capozzi and 6 more

Abstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Stephanie IserKarl Landsteiner University of Health Sciences, Dr. Karl-Dorrek-Straße 30, 3500 Krems, Austria.
Sarah HintermairDepartment of General and Thoracic Surgery, University Hospital Krems, Mitterweg 10, 3500 Krems, Austria.
Alexander VargaDepartment of Pathology, University Hospital Krems, 3500 Krems, Austria.
Ali ÇelikDepartment of Thoracic Surgery, School of Medicine, Gazi University, Besevler, 06500 Ankara, Turkey.
Muhammet SayanDepartment of Thoracic Surgery, School of Medicine, Gazi University, Besevler, 06500 Ankara, Turkey.
Aykut KankoçDepartment of Thoracic Surgery, School of Medicine, Gazi University, Besevler, 06500 Ankara, Turkey.ORCID 0000-0001-5048-6115
Nalan AkyürekDepartment of Pathology, School of Medicine, Gazi University, Besevler, 06500 Ankara, Turkey.
Betül ÖğütDepartment of Pathology, School of Medicine, Gazi University, Besevler, 06500 Ankara, Turkey.
Pietro BertoglioDivision of Thoracic Surgery, IRCCS Azienda Ospedaliero Universitaria di Bologna, 40138 Bologna, Italy.ORCID 0000-0002-6267-0099
Enrico CapozziDivision of Thoracic Surgery, IRCCS Azienda Ospedaliero Universitaria di Bologna, 40138 Bologna, Italy.
Piergiorgio SolliDivision of Thoracic Surgery, IRCCS Azienda Ospedaliero Universitaria di Bologna, 40138 Bologna, Italy.
Luigi VenturaBarts Thorax Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London EC1A 7BS, UK.ORCID 0000-0002-4023-0578
David WallerBarts Thorax Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London EC1A 7BS, UK.
Michael WeberDivision of Biostatistics and Data Science, Department of General Health Studies, Karl Landsteiner University of Health Sciences, Dr. Karl-Dorrek-Straße 30, 3500 Krems, Austria.
Elisabeth StubenbergerDepartment of General and Thoracic Surgery, University Hospital Krems, Mitterweg 10, 3500 Krems, Austria.
Bahil GhanimKarl Landsteiner University of Health Sciences, Dr. Karl-Dorrek-Straße 30, 3500 Krems, Austria.ORCID 0000-0002-6563-5643

Funding

Karl Landsteiner University of Health Sciences ATU 67837709
6 · The paper itself

Abstract

Evoked from asbestos-induced inflammation, pleural mesothelioma represents a fatal diagnosis. Therapy ranges from nihilism to aggressive multimodality regimens. However, it is still unclear who ultimately benefits from which treatment. We aimed to re-challenge inflammatory-related biomarkers' prognostic value in times of modern immune-oncology and lung-sparing surgery. The biomarkers (leukocytes, hemoglobin, platelets, neutrophils, lymphocytes, monocytes, neutrophil-lymphocyte ratio (NLR), lymphocyte-monocyte ratio (LMR), platelet-lymphocyte ratio (PLR), C-reactive protein (CRP)) and clinical characteristics (age, sex, histology, therapy) of 98 PM patients were correlated to overall survival (OS). The median OS was 19.4 months. Significant OS advantages (Log-Rank) were observed in multimodal treatment vs. others (26.1 vs. 7.2 months,

Indexed as

multimodal therapyplateletspleural mesotheliomapleurectomy/decorticationPLRprognostic biomarkers

Identifiers

PMID38201520
PMCPMC10778470

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.