Evidence map›Paper›PMID 38201530›Full record

ArticleCancers2023

Commensal Fecal Microbiota Profiles Associated with Initial Stages of Intestinal Mucosa Damage: A Pilot Study.

Sergio Ruiz-Saavedra, Silvia Arboleya, Alicja M Nogacka, Carmen González Del Rey, Adolfo Suárez, Ylenia Diaz, Miguel Gueimonde, Nuria Salazar, Sonia González, Clara G de Los Reyes-Gavilán

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Characterization of the gut microbiome of wildFrontiers in microbiomes · 2026
    Article
  6. Article
  7. Article
  8. Observational
  9. Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Sergio Ruiz-SaavedraDepartment of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias (IPLA-CSIC), 33300 Villaviciosa, Spain.ORCID 0000-0002-6834-9060
Silvia ArboleyaDepartment of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias (IPLA-CSIC), 33300 Villaviciosa, Spain.ORCID 0000-0002-6155-5822
Alicja M NogackaDepartment of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias (IPLA-CSIC), 33300 Villaviciosa, Spain.ORCID 0000-0001-8300-6149
Carmen González Del ReyDepartment of Anatomical Pathology, Central University Hospital of Asturias (HUCA), 33011 Oviedo, Spain.
Adolfo SuárezDiet, Microbiota and Health Group, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain.ORCID 0000-0001-7149-6814
Ylenia DiazDigestive Service, Carmen and Severo Ochoa Hospital, 33819 Cangas del Narcea, Spain.
Miguel GueimondeDepartment of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias (IPLA-CSIC), 33300 Villaviciosa, Spain.ORCID 0000-0002-0192-901X
Nuria SalazarDepartment of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias (IPLA-CSIC), 33300 Villaviciosa, Spain.ORCID 0000-0003-1435-7628
Sonia GonzálezDiet, Microbiota and Health Group, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain.ORCID 0000-0003-2602-7036
Clara G de Los Reyes-GavilánDepartment of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias (IPLA-CSIC), 33300 Villaviciosa, Spain.ORCID 0000-0001-9396-6311
Instituto de Productos Lácteos de Asturias · ESHospital Universitario Central de Asturias · ESHospital Carmen y Severo Ochoa · ESUniversidad de Oviedo · ES

Funding

Gobierno del Principado de Asturias AYUD/2021/50981Ministerio de Ciencia e Innovación PID2022-140410OB-I00Ministerio de Ciencia e Innovación RTI2018-098288-B-I00
6 · The paper itself

Abstract

Progressive intestinal mucosal damage occurs over years prior to colorectal cancer (CRC) development. The endoscopic screening of polyps and histopathological examination are used clinically to determine the risk and progression of mucosal lesions. We analyzed fecal microbiota compositions using 16S rRNA gene-based metataxonomic analyses and the levels of short-chain fatty acids (SCFAs) using gas chromatography in volunteers undergoing colonoscopy and histopathological analyses to determine the microbiota shifts occurring at the early stages of intestinal mucosa alterations. The results were compared between diagnosis groups (nonpathological controls and polyps), between samples from individuals with hyperplastic polyps or conventional adenomas, and between grades of dysplasia in conventional adenomas. Some microbial taxa from the

Indexed as

conventional adenomasfecal microbiotahyperplastic polypsintestinal mucosaintestinal polyps

Identifiers

PMID38201530
PMCPMC10778549
OpenAlexW4390176230

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.