Evidence map›Paper›PMID 38202597›Full record

ArticleMolecules (Basel, Switzerland)2023

Design and Synthesis of Novel Indole Ethylamine Derivatives as a Lipid Metabolism Regulator Targeting PPARα/CPT1 in AML12 Cells.

Yu-Chen Liu, Gang Wei, Zhi-Qiang Liao, Fang-Xin Wang, Chunxiao Zong, Jiannan Qiu, Yifei Le, Zhi-Ling Yu, Seo Young Yang, Heng-Shan Wang and 2 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Activation of Focal Adhesion Pathway byAnimals : an open access journal from MDPI · 2025
    Article
  2. Peptides fromMarine drugs · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Yu-Chen LiuCollege of Life Science, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Gang WeiState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources/Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), School of Chemistry and Pharmaceutical Sciences, Collaborative Innovation Center for Guangxi Ethnic Medicine, Guangxi Normal University, Guilin 541004, China.
Zhi-Qiang LiaoState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources/Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), School of Chemistry and Pharmaceutical Sciences, Collaborative Innovation Center for Guangxi Ethnic Medicine, Guangxi Normal University, Guilin 541004, China.
Fang-Xin WangState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources/Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), School of Chemistry and Pharmaceutical Sciences, Collaborative Innovation Center for Guangxi Ethnic Medicine, Guangxi Normal University, Guilin 541004, China.ORCID 0000-0002-7981-2495
Chunxiao ZongCollege of Life Science, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Jiannan QiuCollege of Life Science, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Yifei LeCollege of Life Science, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Zhi-Ling YuSchool of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.ORCID 0000-0002-2979-9608
Seo Young YangDepartment of Biology Education, Teachers College and Institute for Phylogenomics and Evolution, Kyungpook National University, Daegu 41566, Republic of Korea.ORCID 0000-0002-5248-1374
Heng-Shan WangState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources/Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), School of Chemistry and Pharmaceutical Sciences, Collaborative Innovation Center for Guangxi Ethnic Medicine, Guangxi Normal University, Guilin 541004, China.
Xiao-Bing DouCollege of Life Science, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Cai-Yi WangCollege of Life Science, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Zhejiang Chinese Medical University · CNGuangxi Normal University · CNHong Kong Baptist University · HKKyungpook National University · KR

Funding

Key Project of Ningbo Natural Science Foundation 2022J280Key projects of agricultural and social development of Hangzhou 202204A04National Natural Science Foundation of China 21977021National Natural Science Foundation of China 22201050National Natural Science Foundation of China 82374102State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guang-xi Normal University) CMEMR2023-B09Zhejiang Natural Science Foundation LZ21H030001
6 · The paper itself

Abstract

Peroxisome proliferator-activated receptor alpha (PPARα) and carnitine palmitoyltransferase 1 (CPT1) are important targets of lipid metabolism regulation for nonalcoholic fatty liver disease (NAFLD) therapy. In the present study, a set of novel indole ethylamine derivatives (

Indexed as

Antipsychotic AgentsNon-alcoholic Fatty Liver DiseaseCarnitine O-PalmitoyltransferaseEthylaminesHumansIndolesLipaseLipid MetabolismOleic AcidPPAR alphaAntipsychotic AgentsCarnitine O-PalmitoyltransferaseethylamineEthylaminesIndolesLipaseOleic AcidPPAR alphaCPT1indole ethylamine derivativesNAFLDPPARα

Identifiers

PMID38202597
PMCPMC10779794
OpenAlexW4389937939

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.