Evidence map›Paper›PMID 38203312›Full record

ArticleInternational journal of molecular sciences2023

A Novel Role for DOC2B in Ameliorating Palmitate-Induced Glucose Uptake Dysfunction in Skeletal Muscle Cells via a Mechanism Involving β-AR Agonism and Cofilin.

Jinhee Hwang, Rekha Balakrishnan, Eunjin Oh, Rajakrishnan Veluthakal, Debbie C Thurmond

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Jinhee HwangDepartment of Molecular and Cellular Endocrinology, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute at City of Hope, Duarte, CA 91010, USA.
Rekha BalakrishnanDepartment of Molecular and Cellular Endocrinology, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute at City of Hope, Duarte, CA 91010, USA.ORCID 0000-0002-9724-5578
Eunjin OhDepartment of Molecular and Cellular Endocrinology, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute at City of Hope, Duarte, CA 91010, USA.ORCID 0009-0003-9437-0570
Rajakrishnan VeluthakalDepartment of Molecular and Cellular Endocrinology, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute at City of Hope, Duarte, CA 91010, USA.
Debbie C ThurmondDepartment of Molecular and Cellular Endocrinology, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute at City of Hope, Duarte, CA 91010, USA.
City of Hope · USKorea University · KR

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI John Charles Williams · 1985 to 2026
$86.3M
Regulation of Glucose Homeostasis by Munc18 ProteinsR01DK067912 · NIDDK · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI THURMOND, DEBBIE C · 2004 to 2023
$6.5M
Targeting PAK1 to improve functional beta-cell mass and insulin sensitivityR01DK102233 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI THURMOND, DEBBIE C, VELUTHAKAL, RAJAKRISHNAN · 2014 to 2024
$3.3M
DOC2B-based therapeutics for prevention/remediation of type 2 diabetesR01DK112917 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI THURMOND, DEBBIE C · 2018 to 2021
$1.7M
NCI NIH HHS P30 CA033572NIDDK NIH HHS R01 DK067912NIDDK NIH HHS R01 DK102233NIDDK NIH HHS R01 DK112917NIH HHS DK067912NIH HHS DK102233NIH HHS DK112917NIH HHS P30CA33572
6 · The paper itself

Abstract

Diet-related lipotoxic stress is a significant driver of skeletal muscle insulin resistance (IR) and type 2 diabetes (T2D) onset. β

Indexed as

Diabetes Mellitus, Type 2Insulin ResistanceActin Depolymerizing FactorsAnimalsCalcium-Binding ProteinsGlucoseHumansMuscle, SkeletalNerve Tissue ProteinsPalmitatesRatsActin Depolymerizing FactorsCalcium-Binding ProteinsDOC2B protein, humanGlucoseNerve Tissue ProteinsPalmitatescofilinDOC2Bglucose uptakeGLUT4insulin resistancelipotoxic stresspalmitateskeletal muscletype 2 diabetesβ-adrenergic receptor

Identifiers

PMID38203312
PMCPMC10779393
OpenAlexW4390050824

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.