Evidence map›Paper›PMID 38203682›Full record

ArticleInternational journal of molecular sciences2023

Characterization of Progranulin Gene Mutations in Portuguese Patients with Frontotemporal Dementia.

Maria Rosário Almeida, Miguel Tábuas-Pereira, Inês Baldeiras, Marisa Lima, João Durães, João Massano, Madalena Pinto, Catarina Cruto, Isabel Santana

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Phenotypic diversity of frontotemporal lobar degeneration in two novel GRN variants from Colombia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Molecular Mechanisms of Dementia 2.0.International journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Maria Rosário AlmeidaCNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.
Miguel Tábuas-PereiraNeurology Department, Centro Hospitalar e Universitário de Coimbra, 3004-561 Coimbra, Portugal.ORCID 0000-0002-3988-614X
Inês BaldeirasCNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.ORCID 0000-0002-8106-7308
Marisa LimaNeurology Department, Centro Hospitalar e Universitário de Coimbra, 3004-561 Coimbra, Portugal.
João DurãesNeurology Department, Centro Hospitalar e Universitário de Coimbra, 3004-561 Coimbra, Portugal.ORCID 0000-0001-9671-593X
João MassanoNeurology Department, Centro Hospitalar Universitário de São João, 4200-319 Porto, Portugal.ORCID 0000-0002-5791-7149
Madalena PintoNeurology Department, Centro Hospitalar Universitário de São João, 4200-319 Porto, Portugal.
Catarina CrutoNeurology Department, Hospital Pedro Hispano, Unidade Local de Saúde de Matosinhos, 4464-513 Matosinhos, Portugal.
Isabel SantanaCNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.
Hospitais da Universidade de Coimbra · PTUniversity of Coimbra · PTHospital de São João · PTHospital Pedro Hispano · PT

Funding

Fundação para a Ciência e Tecnologia PTDC/MEC-NEU/4814/2020
6 · The paper itself

Abstract

In Portugal, heterozygous loss-of-function mutations in the progranulin (

Indexed as

Frontotemporal DementiaPick Disease of the BrainHumansMutationPortugalProgranulinsGRN protein, humanProgranulinsfrontotemporal dementiaGRN mutationslow PGRN levelsmechanism of haploinsufficiency

Identifiers

PMID38203682
PMCPMC10778719
OpenAlexW4390467449

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.