Evidence map›Paper›PMID 38204261›Full record

ArticleAnti-cancer agents in medicinal chemistry2024

Turmeric Extract-loaded Selenium Nanoparticles Counter Doxorubicin-induced Hepatotoxicity in Mice

Barakat M ALRashdi, Mohamed M Hussein, Rawan M Mohammed, Nada W Abdelhamed, Maran E Asaad, Mubarak Alruwaili, Saad M Alrashidi, Ola A Habotta, Ahmed E Abdel Moneim, Shimaa S Ramadan

Abstract read
PubMed Publisher
In one paragraph

Article in Anti-cancer agents in medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Barakat M ALRashdiDepartment of Biology, College of Science, Jouf University, Sakaka, 72388, Saudi Arabia.
Mohamed M HusseinDepartment of Chemistry, Faculty of Science, Helwan University, Cairo, Egypt.
Rawan M MohammedDepartment of Chemistry, Faculty of Science, Helwan University, Cairo, Egypt.
Nada W AbdelhamedDepartment of Chemistry, Faculty of Science, Helwan University, Cairo, Egypt.
Maran E AsaadDepartment of Chemistry, Faculty of Science, Helwan University, Cairo, Egypt.
Mubarak AlruwailiDepartment of Internal Medicine, College of Medicine, Jouf University, Sakaka, Saudi Arabia.
Saad M AlrashidiConsultant Radiation Oncology, Comprehensive Cancer Centre, King Fahad Medical City & College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Ola A HabottaDepartment of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt.
Ahmed E Abdel MoneimDepartment of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt.ORCID 0000-0002-2654-2591
Shimaa S RamadanDepartment of Chemistry, Faculty of Science, Helwan University, Cairo, Egypt.

Funding

Deanship of Scientific Research at Jouf University DSR-2021-03-03112
6 · The paper itself

Abstract

backgroundDoxorubicin (DOX) is an antitumor anthracycline used to treat a variety of malignancies; however, its clinical use is associated with noticeable hepatotoxicity. Therefore, the current study was designed to delineate if biosynthesized SeNPs with turmeric extract (Tur-SeNPs) could alleviate DOX-induced hepatic adverse effects.

methodsMice were orally post-treated with Tur extract, Tur-SeNPs, or N-acetyl cysteine after the intraperitoneal injection of DOX.

resultsOur findings have unveiled a remarkable liver attenuating effect in DOX-injected mice post-treated with Tur-SeNPs. High serum levels of ALT, AST, ALP, and total bilirubin induced by DOX were significantly decreased by Tur-SeNPs therapy. Furthermore, Tur-SeNPs counteracted DOX-caused hepatic oxidative stress, indicated by decreased MDA and NO levels along with elevated levels of SOD, CAT, GPx, GR, GSH, and mRNA expression levels of Nrf-2. Noteworthily, decreased hepatic IL-1β, TNF-α, and NF-κB p65 levels in addition to downregulated iNOS gene expression in Tur-SeNPs-treated mice have indicated their potent antiinflammatory impact. Post-treatment with Tur-SeNPs also mitigated the hepatic apoptosis evoked by DOX injection. A liver histological examination confirmed the biochemical and molecular findings.

conclusionsIn brief, the outcomes have demonstrated Tur loaded with nanoselenium to successfully mitigate the liver damage induced by DOX via blocking oxidative stress, and inflammatory and apoptotic signaling.

Indexed as

ApoptosisCytokinesDoxorubicinNanoparticlesOxidative StressPlant ExtractsSeleniumAnimalsAntibiotics, AntineoplasticCell ProliferationChemical and Drug Induced Liver InjuryCurcumaDose-Response Relationship, DrugMaleMiceStructure-Activity RelationshipAntibiotics, AntineoplasticCytokinesDoxorubicinPlant ExtractsSeleniumturmeric extractapoptosisdoxorubicinhepatotoxicityNanoseleniumoxidative stress.turmeric extract

Identifiers

PMID38204261

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.