Evidence map›Paper›PMID 38206338›Full record

ArticleInternational urogynecology journal2024

Functional Anatomy of Urogenital Hiatus Closure: the Perineal Complex Triad Hypothesis.

John O DeLancey, Fernanda Pipitone, Mariana Masteling, Bing Xie, James A Ashton-Miller, Luyun Chen

Open access · greenAbstract read
In one paragraph

Article in International urogynecology journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
7.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. T‑shaped sling with modified posterior pelvic reconstruction: a technical note with video vignette.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2025
    Pooled it
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  15. Neuromodulation Improves Stress Urinary Incontinence-Like Deficits in Female Rabbits.IEEE open journal of engineering in medicine and biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

John O DeLanceyDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, 48109, USA. delancey@med.umich.edu.ORCID 0000-0002-1012-7713
Fernanda PipitoneDepartment of Obstetrics and Gynecology, University of São Paulo, São Paulo, Brazil.
Mariana MastelingDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.
Bing XieDepartment of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China.
James A Ashton-MillerDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.
Luyun ChenDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, 48109, USA.
University of Michigan · USPeking University · CNUniversidade de São Paulo · BR

Funding

Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lona Mody, RAYMOND L YUNG · 2004 to 2026
$29.2M
Development of 21st Century Concepts and Tools for Quantifying Urethral Failure Mechanisms that Cause Urinary IncontinenceRC2DK122379 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ASHTON-MILLER, JAMES ANTHONY, DELANCEY, JOHN O.L. · 2019 to 2024
$5.7M
Using a mechanistic classification scheme to identify the causes of anterior vaginal wall prolapse and develop a validated surgical planning systemR01HD094954 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, LUYUN · 2018 to 2020
$935k
NCATS NIH HHS UL1 TR002240NIA NIH HHS P30 AG024824NICHD NIH HHS R01 HD094954NIDDK NIH HHS RC2 DK122379NIH HHS R01 HD094954NIH HHS RC2 DK122379
6 · The paper itself

Abstract

introductionUrogenital hiatus enlargement is a critical factor associated with prolapse and operative failure. This study of the perineal complex was performed to understand how interactions among its three structures: the levator ani, perineal membrane, and perineal body-united by the vaginal fascia-work to maintain urogenital hiatus closure.

methodsMagnetic resonance images from 30 healthy nulliparous women with 3D reconstruction of selected subjects were used to establish overall geometry. Connection points and lines of action were based on perineal dissection in 10 female cadavers (aged 22-86 years), cross sections of 4 female cadavers (aged 14-35 years), and histological sections (cadavers aged 16 and 21 years).

resultsThe perineal membrane originates laterally from the ventral two thirds of the ischiopubic rami and attaches medially to the perineal body and vaginal wall. The levator ani attaches to the perineal membrane's cranial surface, vaginal fascia, and the perineal body. The levator line of action in 3D reconstruction is oriented so that the levator pulls the medial perineal membrane cranio-ventrally. In cadavers, simulated levator contraction and relaxation along this vector changes the length of the membrane and the antero-posterior diameter of the urogenital hiatus. Loss of the connection of the left and right perineal membranes through the perineal body results in diastasis of the levator and a widened hiatus, as well as a downward rotation of the perineal membrane.

conclusionInterconnections involving the levator ani muscles, perineal membrane, perineal body, and vaginal fascia form the perineal complex surrounding the urogenital hiatus in an arrangement that maintains hiatal closure.

Indexed as

Pelvic FloorPerineumCadaverFasciaFemaleHumansHypertrophyLevator aniPathophysiology of pelvic organ prolapsePelvic floor birth injuryPerineal bodyPerineal membraneUrogenital and levator hiatus

Identifiers

PMID38206338
PMCPMC11060667
OpenAlexW4390744227

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.