ArticleLipids in health and disease2024
Impact of baseline and trajectory of the atherogenic index of plasma on incident diabetic kidney disease and retinopathy in participants with type 2 diabetes: a longitudinal cohort study.
Article in Lipids in health and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Atherogenic index of plasma and risk of diabetic nephropathy in type 2 diabetes: A meta‑analysis.Biomolecules & biomedicine · 2025Pooled it
- Atherogenic lipid indices and diabetic retinopathy in type 2 diabetes: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Prognostic value of triglyceride-derived metabolic parameters for micro- and macrovascular complications and mortality in individuals with type 2 diabetes: The Rio de Janeiro type 2 diabetes cohort study.Diabetic medicine : a journal of the British Diabetic Association · 2026Article
- Predicting 1-Year Renal Outcomes in Patients with Diabetic Kidney Disease in CKD Stages 3 to 4: A Multimodal Machine Learning Approach Fusing Clinical Composites and Pathology Images.Research (Washington, D.C.) · 2026Article
- Atherogenic index of plasma predicts progression of diabetic kidney disease.Frontiers in medicine · 2026Article
- Association between the atherogenic index of plasma and chronic kidney disease: an evaluation of an adult population of American patients with diabetes mellitus.Renal failure · 2025Article
- Association of atherogenic index of plasma with cardiovascular disease mortality in patients with type 2 diabetes mellitus and diabetic kidney disease: a cross-sectional study.BMC cardiovascular disorders · 2025Article
- Atherogenic index of plasma and its 5-year changes associated with type 2 diabetes risk: a 10-Year cohort study.Cardiovascular diabetology · 2025Article
- Association of atherogenic index of plasma with kidney dysfunction in diabetic individuals: findings from two national population-based studies.BMC endocrine disorders · 2025Article
- Association of atherogenic index of plasma trajectory with the incidence of cardiovascular disease over a 12-year follow-up: findings from the ELSA cohort study.Cardiovascular diabetology · 2025Article
- Relationship between plasma atherogenic index and incidence of cardiovascular diseases in Chinese middle-aged and elderly people.Scientific reports · 2025Article
- Baseline atherogenic index of plasma and its trajectory predict onset of type 2 diabetes in a health screened adult population: a large longitudinal study.Cardiovascular diabetology · 2025Article
- Association between atherogenic index of plasma and type 2 diabetic complications: a cross-sectional study.Frontiers in endocrinology · 2025Article
- Correlation between the atherogenic index of plasma and risk of diabetic retinopathy.Frontiers in medicine · 2025Article
- Novel Lipid Biomarkers and Microvascular Complications in Patients with Diabetes Mellitus: A Systematic Review and Meta-analysis.Clinical medicine insights. Endocrinology and diabetes · 2025Article
- Can lipid indices aid in predicting diabetic kidney disease? Findings from a cross-sectional, matched case-control study.PloS one · 2025Article
- Impact of Lipid Parameters on Visual Acuity Change in Non-Arteritic Anterior Ischemic Optic Neuropathy.Clinical ophthalmology (Auckland, N.Z.) · 2024Article
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13 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSome studies have assessed the predictive role of the atherogenic index of plasma (AIP) for macrovascular diseases. This prospective investigation aimed to elucidate whether AIP is associated with diabetic kidney disease (DKD) and diabetic retinopathy (DR) incidence.
methodsThe data were extracted from 4831 participants, of whom 2943 and 3360 participants with type 2 diabetes (T2D) were included in the DKD and DR follow-up analyses, respectively. Cox regression models were performed to test the relationships of AIP value at baseline with the risk of incident DKD and DR. Group-based trajectory modelling was utilized to discern AIP trajectories during the follow-up period. Subsequently, logistic regressions were applied to ascertain the influence of AIP trajectories on the incidence of DKD and DR.
resultsDuring the follow-up period, 709 (24.1%) and 193 (5.7%) participants developed DKD and DR, respectively. The median (interquartile range) follow-up time was 24.2 (26.3) months for DKD and 25.7 (27.0) months for DR. According to the multivariate Cox regression models, baseline AIP was positively and linearly related to the occurrence of DKD, with a hazard ratio of 1.75 (95% confidence interval [CI] 1.36-2.26). Three distinct trajectories of AIP were identified throughout the follow-up time: Low (31.4%), Median (50.2%), and High (18.3%). Compared to participants with the Low AIP trajectory, those with High and Median AIP trajectories presented 117% (95% CI: 1.62-2.91) and 84% (95% CI 1.46-2.32) greater odds of developing DKD, respectively. However, neither baseline levels nor trajectories of AIP were shown to be related to DR after adjusting for confounding factors.
conclusionsBaseline levels and trajectories of AIP were independently related to elevated DKD risk, indicating that AIP could be used as a predictor for identifying T2D participants at higher risk of DKD. No association between AIP and DR was detected.
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