Evidence map›Paper›PMID 38214784›Full record

ArticleCellular and molecular life sciences : CMLS2024

Increasing HbA1c is associated with reduced CD8

Katina D Hulme, Zhen Wei Marcus Tong, Louise C Rowntree, Carolien E van de Sandt, Katharina Ronacher, Emma J Grant, Emily S Dorey, Linda A Gallo, Stephanie Gras, Katherine Kedzierska and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

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  13. Pathology of Diabetes-Induced Immune Dysfunction.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Katina D HulmeSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia.ORCID http://orcid.org/0000-0003-1322-0136
Zhen Wei Marcus TongSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia.
Louise C RowntreeDepartment of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia.
Carolien E van de SandtDepartment of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia.
Katharina RonacherMater Research Institute, Translational Research Institute, The University of Queensland, Brisbane, Australia.
Emma J GrantDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, VIC, Australia.
Emily S DoreyMater Research Institute, Translational Research Institute, The University of Queensland, Brisbane, Australia.
Linda A GalloSchool of Biomedical Sciences, The University of Queensland, St Lucia, QLD, Australia.
Stephanie GrasDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, VIC, Australia.
Katherine KedzierskaDepartment of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia.
Helen L BarrettMater Research Institute, Translational Research Institute, The University of Queensland, Brisbane, Australia.
Kirsty R ShortSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia. k.short@uq.edu.au.
The University of Queensland · AUThe University of Melbourne · AUTranslational Research Institute · AULa Trobe University · AU

Funding

ARC-DECRA DE200100185ARC-DECRA DE210101479National Health and Medical Research Council 1159272National Health and Medical Research Council 1173871National Health and Medical Research Council 2007919
6 · The paper itself

Abstract

Diabetes mellitus is on the rise globally and is a known susceptibility factor for severe influenza virus infections. However, the mechanisms by which diabetes increases the severity of an influenza virus infection are yet to be fully defined. Diabetes mellitus is hallmarked by high glucose concentrations in the blood. We hypothesized that these high glucose concentrations affect the functionality of CD8

Indexed as

Diabetes MellitusHyperglycemiaInfluenza A virusInfluenza, HumanCD8-Positive T-LymphocytesGlucoseGlycated HemoglobinHumansLeukocytes, MononuclearReceptors, Antigen, T-CellTumor Necrosis Factor-alphaGlucoseGlycated HemoglobinReceptors, Antigen, T-CellTumor Necrosis Factor-alphaAdaptive immune responseHigh glucoseHyperglycemiaT cell receptor complex

Identifiers

PMID38214784
PMCPMC10786977
OpenAlexW4390795030

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.