Evidence map›Paper›PMID 38214908›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2024

Mannitol and hyponatremia regulate cardiac ventricular conduction in the context of sodium channel loss of function.

Grace A Blair, Xiaobo Wu, Chandra Bain, Mark Warren, Gregory S Hoeker, Steven Poelzing

Abstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Article
  3. Cardiac Impulse Propagation: An Integrated View.JACC. Basic to translational science · 2026
    Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Grace A BlairGraduate Program in Translational Biology, Medicine, and Health, Virginia Polytechnic Institute and State University, Roanoke, Virginia, United States.ORCID 0000-0002-5633-5497
Xiaobo WuCenter for Vascular and Heart Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia, United States.ORCID 0000-0002-3136-5059
Chandra BainCenter for Vascular and Heart Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia, United States.ORCID 0000-0002-5308-5509
Mark WarrenCenter for Vascular and Heart Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia, United States.
Gregory S HoekerCenter for Vascular and Heart Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia, United States.ORCID 0000-0002-3917-4791
Steven PoelzingGraduate Program in Translational Biology, Medicine, and Health, Virginia Polytechnic Institute and State University, Roanoke, Virginia, United States.ORCID 0000-0002-6979-1264

Funding

Role of the Extracellular Space as a Modulator of the Cardiac Gap Junction - Conduction Velocity RelationshipR01HL102298 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI POELZING, STEVEN · 2011 to 2020
$3.9M
Arrhythmia Mechanisms Modulated by Intercalated Disc Extracellular NanodomainsR01HL159097 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Steven Poelzing · 2023 to 2026
$2.5M
Unmasking Conduction Deficits in the Scn5a+/- Mouse Model of Brugada SyndromeF31HL160172 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI BONSON, GRACE ANNA · 2021 to 2022
$80k
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) F31HL160172HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL102298HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL159097NHLBI NIH HHS F31 HL160172NHLBI NIH HHS R01 HL102298NHLBI NIH HHS R01 HL159097
6 · The paper itself

Abstract

Scn5a heterozygous null (

Indexed as

Brugada SyndromeHyponatremiaAction PotentialsAnimalsGuinea PigsHeartHeart VentriclesMiceNAV1.5 Voltage-Gated Sodium ChannelSodium ChannelsNAV1.5 Voltage-Gated Sodium ChannelSodium Channelsbasic science researchcongenital heart diseaseelectrophysiologytranslational studies

Identifiers

PMID38214908
PMCPMC11221810

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.