Evidence map›Paper›PMID 38223241›Full record

ArticleAnnals of gastroenterology

Serial rotational thromboelastometry measurements show worsening hypocoagulability in acute-on-chronic liver failure and are associated with the severity of liver disease.

George Kampelos, Larisa Vasilieva, Theodoros Alexopoulos, Iliana Mani, Emilia Hadziyannis, Stavroula Giannouli, Sofia Manioudaki, Efrosyni Nomikou, Alexandra Alexopoulou

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

George Kampelos2 Department of Internal Medicine and Research Laboratory, Medical School, National and Kapodistrian University of Athens, Hippokration General Hospital (George Kampelos, Iliana Mani, Emilia Hadziyannis, Stavroula Giannouli, Alexandra Alexopoulou).
Larisa VasilievaGastroenterology Department, Alexandra General Hospital (Larisa Vasilieva).
Theodoros AlexopoulosGastroenterology Department, National and Kapodistrian University of Athens, Medical School, Laiko General Hospital (Theodoros Alexopoulos).
Iliana Mani2 Department of Internal Medicine and Research Laboratory, Medical School, National and Kapodistrian University of Athens, Hippokration General Hospital (George Kampelos, Iliana Mani, Emilia Hadziyannis, Stavroula Giannouli, Alexandra Alexopoulou).
Emilia Hadziyannis2 Department of Internal Medicine and Research Laboratory, Medical School, National and Kapodistrian University of Athens, Hippokration General Hospital (George Kampelos, Iliana Mani, Emilia Hadziyannis, Stavroula Giannouli, Alexandra Alexopoulou).
Stavroula Giannouli2 Department of Internal Medicine and Research Laboratory, Medical School, National and Kapodistrian University of Athens, Hippokration General Hospital (George Kampelos, Iliana Mani, Emilia Hadziyannis, Stavroula Giannouli, Alexandra Alexopoulou).
Sofia ManioudakiIntensive Care Unit, Sismanogleio General Hospital of Athens (Sofia Manioudaki).
Efrosyni NomikouBlood Bank and Haemophilia Unit, Hippokratio General Hospital of Athens (Efrosyni Nomikou), Athens, Greece.
Alexandra Alexopoulou2 Department of Internal Medicine and Research Laboratory, Medical School, National and Kapodistrian University of Athens, Hippokration General Hospital (George Kampelos, Iliana Mani, Emilia Hadziyannis, Stavroula Giannouli, Alexandra Alexopoulou).
Alexandra Hospital · GBHippocration General Hospital · GRLaiko General Hospital of Athens · GRSismanoglio General Hospital · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Viscoelastic tests are used to better understand the complex picture of hemostasis in cirrhosis. Limited data exist regarding the clinical relevance of rotational thromboelastometry (ROTEM) in acute-on-chronic liver failure (ACLF) or acute decompensation (AD). We examined the pattern and role of sequential observations of 9 ROTEM components in both ACLF and AD groups. Method: ROTEM measurements were compared within and between groups at 3 time points: on admission (T1), at 24 h (T2) and 48 h post-admission (T3). Results: Forty-two consecutive patients (22 ACLF, 20 AD) were included. ROTEM determinants exhibited significant hypocoagulable deterioration in ACLF but not in AD over the 3 time points in clot formation time (CFT) Conclusions: ROTEM measurements indicated worsening hypocoagulability shortly post-admission compared to baseline in ACLF, but remained stable in AD. The hypocoagulable derangement was mostly correlated with the severity of liver disease and higher short-term mortality, but not more bleeding episodes.

Indexed as

acute decompensationAcute-on-chronic liver failurerotational thromboelastometry “hypocoagulable” profile

Identifiers

PMID38223241
PMCPMC10785023
OpenAlexW4390889355

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.