ArticleBMC medicine2024
Associations between long-term night shift work and incidence of chronic obstructive pulmonary disease: a prospective cohort study of 277,059 UK Biobank participants.
Article in BMC medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Night shift work and the acceleration of chronic kidney disease onset: dose-response relationships, interactions with cardiometabolic genetic risk, and metabolomic mediators.Scandinavian journal of work, environment & health · 2026Article
- Inflammatory marker dynamics in shift work sleep disorder: a data-driven approach among rotating shift workers.Frontiers in neuroscience · 2026Article
- Joint association of cumulative workplace environmental exposures and shift work with long-term work-limiting health conditions: a prospective cohort study from the UK Biobank.BMJ public health · 2026Article
- Effects of in utero tobacco exposure, age of smoking initiation, and environmental pollution on the risk of chronic obstructive pulmonary disease in adulthood: a large scale prospective cohort study.BMC pulmonary medicine · 2025Article
- Air pollution and dynamic transitions of preserved ratio impaired spirometry in UK Biobank.Communications medicine · 2025Article
- Associations between serum lipid profiles and the incidence of chronic obstructive pulmonary disease in the UK Biobank.Journal of health, population, and nutrition · 2025Article
- [Therapeutic effects of natural products on animal models of chronic obstructive pulmonary disease].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Review
- Association of Shift Work and Lifestyle With Aortic Aneurysm Incidence: A Large Prospective Cohort Study in the UK Biobank.Journal of the American Heart Association · 2025Article
- The Association Between Shift Work, Sleep Quality, and Health-Related Quality of Life Among Workers in the Logistics Industry.Journal of community health · 2025Article
- Healthful Plant-Based Dietary Patterns Associated with Reduced Adverse Effects of Air Pollution on COPD: Findings from a Large Cohort Study.Nutrients · 2025Article
- The roles of lifestyle factors and genetic risk in the association between night shift work and cholelithiasis: a prospective cohort study.Frontiers in endocrinology · 2025Article
- Pulmonary tuberculosis during the developmental period contributes to COPD and pre-COPD in mid-to-late adulthood: a retrospective cohort study.Therapeutic advances in respiratory diseaseArticle
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundLittle is known about the effects of night shifts and their interactions with genetic factors on chronic obstructive pulmonary disease (COPD). In this study, we aim to investigate relationships between long-term night shift work exposure and COPD risk, and assess modification effects of genetic predisposition.
methodsA total of 277,059 subjects who were in paid employment or self-employed were included in the UK Biobank. Information on current and lifetime employment was obtained, and a weighted COPD-specific genetic risk score (GRS) was constructed. We used Cox proportional hazard models to investigate associations between night shift work and COPD risk, and their interaction with COPD-specific GRS.
resultsThe cohort study included 277,059 participants (133,063 men [48.03%]; mean [SD] age, 52.71 [7.08] years). During a median follow-up of 12.87 years, we documented 6558 incidents of COPD. From day work, irregular night shifts to regular night shifts, there was an increased trend in COPD incidence (P for trend < 0.001). Compared with day workers, the hazard ratio (HR) and 95% confidence interval (CI) of COPD was 1.28 (1.20, 1.37) for subjects with rarely/sometimes night shifts and 1.49 (1.35, 1.66) for those with permanent night shifts. Besides, the longer durations (especially in subjects with night shifts ≥ 10 years) and increasing monthly frequency of night shifts (in workers with > 8 nights/month) were associated with a higher COPD risk. Additionally, there was an additive interaction between night shifts and genetic susceptibility on the COPD risk. Subjects with permanent night shifts and high genetic risk had the highest risk of COPD (HR: 1.90 [95% CI: 1.63, 2.22]), with day workers with low genetic risk as a reference.
conclusionsLong-term night shift exposure is associated with a higher risk of COPD. Our findings suggest that decreasing the frequency and duration of night shifts may offer a promising approach to mitigating respiratory disease incidence in night shift workers, particularly in light of individual susceptibility.
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