Evidence map›Paper›PMID 38226752›Full record

ArticleAlcohol, clinical & experimental research2023

Maternal and paternal risk factors for fetal alcohol spectrum disorders: Alcohol and other drug use as proximal influences.

Philip A May, Julie M Hasken, Marlene M de Vries, Anna-Susan Marais, Omar Abdul-Rahman, Luther K Robinson, Margaret P Adam, Melanie A Manning, Wendy O Kalberg, David Buckley and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alcohol, clinical & experimental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
7.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 2 countries.

Philip A MayNutrition Research Institute, The University of North Carolina at Chapel Hill, Kannapolis, North Carolina, USA.ORCID https://orcid.org/0000-0003-1939-8701
Julie M HaskenNutrition Research Institute, The University of North Carolina at Chapel Hill, Kannapolis, North Carolina, USA.
Marlene M de VriesDepartment of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Anna-Susan MaraisDepartment of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Omar Abdul-RahmanDepartment of Pediatrics, New York- Presbyterian Weill Cornell Medicine, Columbia University, New York, New York, USA.
Luther K RobinsonDepartment of Pediatrics, State University of New York, Buffalo, New York, USA.
Margaret P AdamDepartment of Pediatrics, University of Washington, Seattle, Washington, USA.
Melanie A ManningDepartment of Pathology and Pediatrics, Stanford University School of Medicine, Stanford, California, USA.
Wendy O KalbergCenter on Alcoholism, Substance Abuse and Addictions, The University of New Mexico, Albuquerque, New Mexico, USA.
David BuckleyCenter on Alcoholism, Substance Abuse and Addictions, The University of New Mexico, Albuquerque, New Mexico, USA.
Soraya SeedatDepartment of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Charles D H ParryDepartment of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.ORCID https://orcid.org/0000-0001-9787-2785
H Eugene HoymeDepartment of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Stellenbosch University · ZAUniversity of New Mexico · USUniversity of North Carolina at Chapel Hill · USCornell University · USSanford Health · USSouth African Medical Research Council · ZAStanford University · USUniversity at Buffalo, State University of New York · USUniversity of Washington · US

Funding

Trajectory of Fetal Alcohol Spectrum Disorders (FASD) Across the Lifespan: Continuing Prevention and Longitudinal EpidemiologyU01AA015134 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAY, PHILIP ALAN · 2009 to 2018
$7.8M
Trajectory of Fetal Alcohol Spectrum Disorders (FASD) Across the Lifespan: Continuing Prevention and Longitudinal EpidemiologyR01AA015134 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAY, PHILIP ALAN · 2006 to 2022
$4.5M
Adventures in the Design and Trial of an Innovative FASD Risk Assessment: Integrating Known Risks with New Measures of Weekly Prenatal Alcohol Exposure, Maternal Mental Health, and Paternal AlcoholR61AA030066 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHEATHAM, CAROL L · 2023 to 2024
$462k
NIAAA NIH HHS R01 AA015134NIAAA NIH HHS R61 AA030066NIAAA NIH HHS U01 AA015134NIAAA NIH HHS U01/R01 AA015134
6 · The paper itself

Abstract

objectiveTo explore and analyze the significance of proximal influences of maternal and paternal traits associated with bearing a child with a fetal alcohol spectrum disorder (FASD).

methodsAggregated, maternal interview-collected data (N = 2515) concerning alcohol, tobacco, and other drug use were examined to determine risk for FASD from seven cross-sectional samples of mothers of first-grade students who were evaluated for a possible diagnosis of FASD.

resultsMothers of children with fetal alcohol syndrome (FAS) reported the highest alcohol use throughout pregnancy, proportion of binge drinking, drinks per drinking day (DDD), drinking days per week, and total drinks per week. Mothers of children with FAS also consumed significantly more alcohol than mothers of children with partial FAS (PFAS), alcohol-related neurodevelopmental disorder (ARND), or typically developing controls. Mothers of children with PFAS and ARND reported similar drinking patterns, which exposed fetuses to 3-4 times more alcohol than mothers of controls, but the PFAS group was more likely than the ARND group to abstain in latter trimesters. Fathers of all children were predominantly drinkers (70%-85%), but more fathers of children with FASD binged heavily on more days than fathers of controls. Compared to the few mothers of controls who used alcohol during pregnancy, the ARND group binge drank more (3+ DDD) throughout pregnancy and drank more DDD before pregnancy and first trimester. Regression analysis, controlling for tobacco use, indicated that mothers who reported drinking <1 DDD were significantly more likely than abstainers to bear a child with FASD (OR = 2.75) as were those reporting higher levels such as 5-5.9 DDD (OR = 32.99). Exclusive, first-trimester maternal drinking increased risk for FASD five times over that of abstinence (p < 0.001, OR = 5.05, 95% CI: 3.88-6.58), first- and second-trimester drinking by 12.4 times, and drinking all trimesters by 16 times (p < 0.001, OR = 15.69, 95% CI: 11.92-20.64). Paternal drinking during and prior to pregnancy, without adjustment, increased the likelihood of FASD significantly (OR = 1.06 and 1.11, respectively), but the significance of both relationships disappeared when maternal alcohol and tobacco use were controlled.

conclusionsDifferences in FASD risk emerged from the examination of multiple proximal variables of maternal alcohol and tobacco use, reflecting increased FASD risk at greater levels of maternal alcohol consumption.

Indexed as

alcohol use while breastfeedingbinge drinkingfetal alcohol spectrum disordersmaternal risk for FASDpaternal risk for FASDprenatal alcohol useSouth Africa

Identifiers

PMID38226752
PMCPMC10792253
OpenAlexW4386966552

What Socratic holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.