Evidence map›Paper›PMID 38228111›Full record

ArticleBlood purification2024

Protein Kinase N1 Level Predicts Acute Kidney Injury in Patients Undergoing Cardiac Surgery: A Prospective Cohort Study.

Lianjiu Su, Fangfang Zhu, Jiahao Zhang, Edward Z Cao, Cheng Yang, Haibing Sun, Xiaofang Jiang, Xiaozhan Wang, Jing Wang, Zhiyong Peng

Abstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood purification, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lianjiu SuDepartment of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Fangfang ZhuDepartment of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Jiahao ZhangDepartment of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Edward Z CaoDepartment of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Cheng YangDepartment of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Haibing SunDepartment of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Xiaofang JiangDepartment of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Xiaozhan WangDepartment of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Jing WangDepartment of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Zhiyong PengDepartment of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe objective of this study was to examine the utility of protein kinase N1 (PKN1) as a biomarker of cardiac surgery-associated AKI (CSA-AKI).

methodsA prospective cohort study of 110 adults undergoing on-pump cardiac surgery was conducted. The associations between post-operative PKN1 and CSA-AKI, AKI severity, need for renal replacement therapy (RRT), duration of AKI, length of ICU stay, and post-operative hospital stay were evaluated.

resultsPatients were categorized into three groups according to PKN1 tertiles. The incidence of CSA-AKI in the third tertile was 3.4-fold higher than that in the first. PKN1 was an independent risk factor for CSA-AKI. The discrimination of PKN1 to CSA-AKI assessed by ROC curve indicated that the AUC was 0.70, and the best cutoff was 5.025 ng/mL. This group (>5.025 ng/mL) was more likely to develop CSA-AKI (p < 0.001). The combined AUC of EuroSCORE, aortic cross-clamp time, and PKN1 was 0.82 (p < 0.001). A higher level of PKN1 was related to increased need for RRT, longer duration of AKI, and length of ICU and post-operative hospital stays.

conclusionsPKN1 could be a potential biomarker for the prediction of CSA-AKI. The combination of PKN1, EuroSCORE, and aortic cross-clamp time was likely to predict the occurrence of CSA-AKI.

Indexed as

Acute Kidney InjuryCardiac Surgical ProceduresProtein Kinase CAgedArea Under CurveBiomarkersFemaleHumansIntensive Care UnitsLength of StayMaleMiddle AgedPostoperative ComplicationsProspective StudiesRenal Replacement TherapyRisk AssessmentBiomarkersProtein Kinase Cprotein kinase NBiomarkerCardiac surgery-associated acute kidney injuryCardiopulmonary bypassPredictionProtein kinase N1

Identifiers

PMID38228111
PMCPMC11151993

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.