Evidence map›Paper›PMID 38228657›Full record

ArticleScientific reports2024

Transcriptomics identifies blunted immunomodulatory effects of vitamin D in people with multiple sclerosis.

Wei Z Yeh, Rodney Lea, Jim Stankovich, Sandeep Sampangi, Louise Laverick, Anneke Van der Walt, Vilija Jokubaitis, Melissa Gresle, Helmut Butzkueven

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Vitamin D: A Bridge between Kidney and Heart.Life (Basel, Switzerland) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Wei Z YehDepartment of Neuroscience, Central Clinical School, Monash University, Alfred Centre, Level 6, 99 Commercial Rd, Melbourne, VIC, 3004, Australia. wei.yeh@monash.edu.
Rodney LeaSchool of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, Australia.
Jim StankovichDepartment of Neuroscience, Central Clinical School, Monash University, Alfred Centre, Level 6, 99 Commercial Rd, Melbourne, VIC, 3004, Australia.
Sandeep SampangiDepartment of Neuroscience, Central Clinical School, Monash University, Alfred Centre, Level 6, 99 Commercial Rd, Melbourne, VIC, 3004, Australia.
Louise LaverickDepartment of Medicine, University of Melbourne, Melbourne, VIC, Australia.
Anneke Van der WaltDepartment of Neuroscience, Central Clinical School, Monash University, Alfred Centre, Level 6, 99 Commercial Rd, Melbourne, VIC, 3004, Australia.
Vilija JokubaitisDepartment of Neuroscience, Central Clinical School, Monash University, Alfred Centre, Level 6, 99 Commercial Rd, Melbourne, VIC, 3004, Australia.
Melissa Gresle *Department of Neuroscience, Central Clinical School, Monash University, Alfred Centre, Level 6, 99 Commercial Rd, Melbourne, VIC, 3004, Australia.
Helmut Butzkueven *Department of Neuroscience, Central Clinical School, Monash University, Alfred Centre, Level 6, 99 Commercial Rd, Melbourne, VIC, 3004, Australia. helmut.butzkueven@monash.edu.
Monash Alfred Psychiatry Research centre · AUMonash University · AUAlfred Health · AUQueensland University of Technology · AUUniversity of Melbourne · AU

Funding

Multiple Sclerosis Australia 19-0735
6 · The paper itself

Abstract

Vitamin D deficiency is a risk factor for developing multiple sclerosis (MS). However, the immune effects of vitamin D in people with MS are not well understood. We analyzed transcriptomic datasets generated by RNA sequencing of immune cell subsets (CD4

Indexed as

Multiple SclerosisCD8-Positive T-LymphocytesGene Expression ProfilingHumansImmunityTumor Necrosis Factor-alphaVitamin DVitaminsTumor Necrosis Factor-alphaVitamin DVitamins

Identifiers

PMID38228657
PMCPMC10792011
OpenAlexW4390901398

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.