Evidence map›Paper›PMID 38229759›Full record

ArticleACS medicinal chemistry letters2024

Synthesis and Evaluation of Benzylamine Inhibitors of Neuropathogenic

Julia M Pomeroy, Muhammad M Khalifa, Jillian E Milanes, Caroline M Palmentiero, James C Morris, Jennifer E Golden

Open access · greenAbstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Julia M PomeroyDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Muhammad M KhalifaSchool of Pharmacy, Division of Pharmaceutical Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
Jillian E MilanesEukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina 29634, United States.
Caroline M PalmentieroEukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina 29634, United States.
James C MorrisEukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina 29634, United States.ORCID https://orcid.org/0000-0003-2515-5714
Jennifer E GoldenDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID https://orcid.org/0000-0002-6813-3710
Clemson University · USUniversity of Wisconsin–Madison · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Lu Mao · 1985 to 2026
$142.6M
Regulation of Cryptosporidium DevelopmentP20GM146584 · NIGMS · CLEMSON UNIVERSITY · PI JAMES Culvin MORRIS · 2022 to 2026
$13.5M
Development of a multiplexed assay in kinetoplastid parasites to identify probes for glycolysisR01AI156382 · NIAID · CLEMSON UNIVERSITY · PI CHRISTENSEN, KENNETH A, GOLDEN, JENNIFER E. · 2021 to 2024
$1.9M
Enolase inhibitors as therapeutic leads for Naegleria fowleri infectionsR21AI171217 · NIAID · CLEMSON UNIVERSITY · PI MORRIS, JAMES CULVIN, MOSEMAN, E. ASHLEY · 2023 to 2024
$468k
NCI NIH HHS P30 CA014520NIAID NIH HHS R01 AI156382NIAID NIH HHS R21 AI171217NIGMS NIH HHS P20 GM146584
6 · The paper itself

Abstract

Current therapy for primary amoebic meningoencephalitis (PAM), a highly lethal brain infection in humans caused by

Identifiers

PMID38229759
PMCPMC10789148
OpenAlexW4390399305

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.