ArticlebioRxiv : the preprint server for biology2023
Macrophages undergo functionally significant reprograming of nucleotide metabolism upon classical activation.
Steven V John, Gretchen L Seim, Billy J Erazo-Flores, John Steill, Jack Freeman, James A Votava, Nicholas L Arp, Xin Qing, Ron Stewart, Laura J Knoll and 1 more
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 3 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
11 authors at 2 institutions in 1 country.
Steven V JohnMorgridge Institute for Research, Madison, WI.
Gretchen L SeimMorgridge Institute for Research, Madison, WI.
Billy J Erazo-FloresCellular and Molecular Pathology Graduate Program, University of Wisconsin-Madison, Madison, WI.
John SteillMorgridge Institute for Research, Madison, WI.
Jack FreemanMorgridge Institute for Research, Madison, WI.
James A VotavaMorgridge Institute for Research, Madison, WI.
Nicholas L ArpMorgridge Institute for Research, Madison, WI.
Xin QingMorgridge Institute for Research, Madison, WI.
Ron StewartMorgridge Institute for Research, Madison, WI.
Laura J KnollCellular and Molecular Pathology Graduate Program, University of Wisconsin-Madison, Madison, WI.
University of Wisconsin–Madison · USMorgridge Institute for Research · US
Funding
UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6MParasitology and Vector Biology Training ProgramT32AI007414 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI Lyric Colleen Bartholomay · 1992 to 2026
$4.5MDevelopment of a human intestinal microphysiological system for the study of immune responses to protozoan parasitesR01AI172874 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI David J Beebe, LAURA J KNOLL · 2023 to 2026
$3.1MMetabolic rewiring coupled to the production of reactive oxygen and nitrogen species (RONS)R35GM147014 · NIGMS · MORGRIDGE INSTITUTE FOR RESEARCH, INC. · PI Jing Fan · 2022 to 2026
$2.1MDynamic Metabolic Reprogramming in Macrophages during Immune ResponseR56AI158958 · NIAID · MORGRIDGE INSTITUTE FOR RESEARCH, INC. · PI FAN, JING · 2022 to 2022
$236kThe molecular mechanism and the functional role of pyruvate dehydrogenase complex regulation in macrophagesF31AI152280 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI SEIM, GRETCHEN · 2021 to 2022
$52kNCI NIH HHS P30 CA014520NIAID NIH HHS F31 AI152280NIAID NIH HHS R01 AI172874NIAID NIH HHS R56 AI158958NIAID NIH HHS T32 AI007414NIGMS NIH HHS R35 GM147014
6 · The paper itselfAbstract
During an immune response, macrophages systematically rewire their metabolism in specific ways to support their diversve functions. However, current knowledge of macrophage metabolism is largely concentrated on central carbon metabolism. Using multi-omics analysis, we identified nucleotide metabolism as one of the most significantly rewired pathways upon classical activation. Further isotopic tracing studies revealed several major changes underlying the substantial metabolomic alterations: 1)
Identifiers
PMID38234794
PMCPMC10793465
OpenAlexW4390343792
What Socratic holds
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