Evidence map›Paper›PMID 38236296›Full record

ArticleCellular and molecular life sciences : CMLS2024

The guanine nucleotide exchange factor RapGEF2 is required for ERK-dependent immediate-early gene (Egr1) activation during fear memory formation.

Sunny Zhihong Jiang, Meishar Shahoha, Hai-Ying Zhang, William Brancaleone, Abdel Elkahloun, Hugo A Tejeda, Uri Ashery, Lee E Eiden

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Rare heterozygous de novo variants in RAPGEF2 are associated with a neurodevelopmental disorder.Genetics in medicine : official journal of the American College of Medical Genetics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Sunny Zhihong Jiang *Section On Molecular Neuroscience, NIMH Intramural Research Program, 9000 Rockville Pike, Building 49, Room 5A38, Bethesda, MD, 20892, USA.
Meishar Shahoha *School of Neurobiology, Biochemistry and Biophysics, George S. Wise Faculty of Life Sciences, and Sagol School of Neuroscience, Tel Aviv University, Sherman Building Rm 719, Ramat Aviv, 69978, Tel Aviv, Israel.
Hai-Ying ZhangSection On Molecular Neuroscience, NIMH Intramural Research Program, 9000 Rockville Pike, Building 49, Room 5A38, Bethesda, MD, 20892, USA.
William BrancaleoneSection On Molecular Neuroscience, NIMH Intramural Research Program, 9000 Rockville Pike, Building 49, Room 5A38, Bethesda, MD, 20892, USA.
Abdel ElkahlounMicroarray Core, NHGRI-IRP, Bethesda, MD, USA.
Hugo A TejedaUnit on Neuromodulation and Synaptic Integration, NIMH-IRP, Bethesda, MD, USA.
Uri AsherySchool of Neurobiology, Biochemistry and Biophysics, George S. Wise Faculty of Life Sciences, and Sagol School of Neuroscience, Tel Aviv University, Sherman Building Rm 719, Ramat Aviv, 69978, Tel Aviv, Israel. uriashery@gmail.com.ORCID http://orcid.org/0000-0001-6338-7888
Lee E EidenSection On Molecular Neuroscience, NIMH Intramural Research Program, 9000 Rockville Pike, Building 49, Room 5A38, Bethesda, MD, 20892, USA. eidenl@mail.nih.gov.ORCID http://orcid.org/0000-0001-7524-944X
Office of Extramural Research · USTel Aviv University · ILNational Human Genome Research Institute · USSynaptic Research (United States) · US

Funding

Chemical Coding Of NeurotransmissionZIAMH002386 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI EIDEN, LEE E. · 2009 to 2025
$25.6M
Unit of Neuromodulation and Synaptic IntegrationZIAMH002970 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI TEJEDA, HUGO · 2019 to 2025
$11.1M
NEUROSECRETORY VESICLED PROTEINS AND CHEMICAL CODING OF NEUROTRANSMISSIONZ01MH002386 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI EIDEN, LEE E. · 1987 to 2008
$3.6M
Intramural NIH HHS Z01 MH002386Israel Science Foundation 2141/20Israel Science Foundation 953/16National Alliance for Research on Schizophrenia and Depression Young Investigator AwardNIMH-IRP MH002386
6 · The paper itself

Abstract

The MAP kinase ERK is important for neuronal plasticity underlying associative learning, yet specific molecular pathways for neuronal ERK activation are undetermined. RapGEF2 is a neuron-specific cAMP sensor that mediates ERK activation. We investigated whether it is required for cAMP-dependent ERK activation leading to other downstream neuronal signaling events occurring during associative learning, and if RapGEF2-dependent signaling impairments affect learned behavior. Camk2α-cre

Indexed as

FearGenes, Immediate-EarlyGuanine Nucleotide Exchange FactorsMemorySignal TransductionAnimalsEarly Growth Response Protein 1MiceProto-Oncogene Proteins c-fosCNrasGEF protein, mouseEarly Growth Response Protein 1Egr1 protein, mouseGuanine Nucleotide Exchange FactorsProto-Oncogene Proteins c-foscAMPc-Fosegr1/zif268Fear learningImmediate early geneMAP kinase

Identifiers

PMID38236296
PMCPMC11071968
OpenAlexW4390975476

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.