Evidence map›Paper›PMID 38238304›Full record

ArticleTranslational psychiatry2024

Morphometric network-based abnormalities correlate with psychiatric comorbidities and gene expression in PCDH19-related developmental and epileptic encephalopathy.

Matteo Lenge, Simona Balestrini, Antonio Napolitano, Davide Mei, Valerio Conti, Giulia Baldassarri, Marina Trivisano, Simona Pellacani, Letizia Macconi, Daniela Longo and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Matteo Lenge *Child Neurology Unit and Laboratories, Neuroscience Department, Meyer Children's Hospital IRCCS, 50139, Florence, Italy.ORCID 0000-0003-2848-621X
Simona Balestrini *Child Neurology Unit and Laboratories, Neuroscience Department, Meyer Children's Hospital IRCCS, 50139, Florence, Italy.
Antonio Napolitano *Medical Physics Department, Bambino Gesù Children's Hospital, IRCCS, 00100, Rome, Italy.
Davide MeiChild Neurology Unit and Laboratories, Neuroscience Department, Meyer Children's Hospital IRCCS, 50139, Florence, Italy.
Valerio ContiChild Neurology Unit and Laboratories, Neuroscience Department, Meyer Children's Hospital IRCCS, 50139, Florence, Italy.
Giulia BaldassarriMedical Physics Department, Bambino Gesù Children's Hospital, IRCCS, 00100, Rome, Italy.
Marina TrivisanoNeurology, Epilepsy and Movement Disorders, Bambino Gesù Children's Hospital, IRCCS, Full Member of European Reference Network EpiCARE, 00165, Rome, Italy.
Simona PellacaniChild Neurology Unit and Laboratories, Neuroscience Department, Meyer Children's Hospital IRCCS, 50139, Florence, Italy.
Letizia MacconiPediatric Radiology Unit, Meyer Children's Hospital IRCCS, 50139, Florence, Italy.
Daniela LongoFunctional and Interventional Neuroimaging Unit, Bambino Gesù Children's Hospital, IRCCS, 00165, Rome, Italy.
Maria Camilla Rossi EspagnetFunctional and Interventional Neuroimaging Unit, Bambino Gesù Children's Hospital, IRCCS, 00165, Rome, Italy.
Simona CappellettiNeurology, Epilepsy and Movement Disorders, Bambino Gesù Children's Hospital, IRCCS, Full Member of European Reference Network EpiCARE, 00165, Rome, Italy.
PCDH19 Clinical Study Group
Ludovico D'IncertiPediatric Radiology Unit, Meyer Children's Hospital IRCCS, 50139, Florence, Italy.
Carmen BarbaChild Neurology Unit and Laboratories, Neuroscience Department, Meyer Children's Hospital IRCCS, 50139, Florence, Italy.
Nicola SpecchioNeurology, Epilepsy and Movement Disorders, Bambino Gesù Children's Hospital, IRCCS, Full Member of European Reference Network EpiCARE, 00165, Rome, Italy.
Renzo GuerriniChild Neurology Unit and Laboratories, Neuroscience Department, Meyer Children's Hospital IRCCS, 50139, Florence, Italy. renzo.guerrini@meyer.it.ORCID 0000-0002-7272-7079
Meyer Children's Hospital · ITBambino Gesù Children's Hospital · ITFondazione Stella Maris · ITIstituto Giannina Gaslini · IT

Funding

Ente Cassa di Risparmio di Firenze (Cash Savings Institution of Florence) Human Brain Optical MappingEuropean Commission (EC) NRRP M6C2Ministero della Salute (Ministry of Health, Italy) RF-2021-12372804Regione Toscana (Tuscany Region) DECODE-EE
6 · The paper itself

Abstract

Protocadherin-19 (PCDH19) developmental and epileptic encephalopathy causes an early-onset epilepsy syndrome with limbic seizures, typically occurring in clusters and variably associated with intellectual disability and a range of psychiatric disorders including hyperactive, obsessive-compulsive and autistic features. Previous quantitative neuroimaging studies revealed abnormal cortical areas in the limbic formation (parahippocampal and fusiform gyri) and underlying white-matter fibers. In this study, we adopted morphometric, network-based and multivariate statistical methods to examine the cortex and substructure of the hippocampus and amygdala in a cohort of 20 PCDH19-mutated patients and evaluated the relation between structural patterns and clinical variables at individual level. We also correlated morphometric alterations with known patterns of PCDH19 expression levels. We found patients to exhibit high-significant reductions of cortical surface area at a whole-brain level (left/right p

Indexed as

Brain DiseasesMental DisordersBrainCadherinsGene ExpressionHumansProtocadherinsSeizuresCadherinsPCDH19 protein, humanProtocadherins

Identifiers

PMID38238304
PMCPMC10796344
OpenAlexW4390971925

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.