Evidence map›Paper›PMID 38238586›Full record

ArticleNature structural & molecular biology2024

The histone chaperone SPT2 regulates chromatin structure and function in Metazoa.

Giulia Saredi, Francesco N Carelli, Stéphane G M Rolland, Giulia Furlan, Sandra Piquet, Alex Appert, Luis Sanchez-Pulido, Jonathan L Price, Pablo Alcon, Lisa Lampersberger and 11 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature structural & molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 8 institutions in 4 countries.

Giulia SarediMRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK. g.saredi@dundee.ac.uk.ORCID http://orcid.org/0000-0002-0798-0959
Francesco N CarelliGurdon Institute, University of Cambridge, Cambridge, UK.
Stéphane G M Rolland *IBS Centre for Genomic Integrity at Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea.
Giulia Furlan *Gurdon Institute, University of Cambridge, Cambridge, UK.
Sandra Piquet *Laboratory of Epigenome Integrity, Epigenetics and Cell Fate Centre, UMR 7216 CNRS - Université Paris Cité, Paris, France.
Alex Appert *Gurdon Institute, University of Cambridge, Cambridge, UK.
Luis Sanchez-PulidoMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Jonathan L PriceGurdon Institute, University of Cambridge, Cambridge, UK.
Pablo AlconMRC Laboratory of Molecular Biology, Cambridge, UK.ORCID http://orcid.org/0000-0002-7435-3859
Lisa LampersbergerGurdon Institute, University of Cambridge, Cambridge, UK.
Anne-Cécile DéclaisMolecular Cell and Developmental Biology Division, School of Life Sciences, University of Dundee, Dundee, UK.ORCID http://orcid.org/0000-0002-1904-6469
Navin B RamakrishnaGurdon Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-2974-9886
Rachel TothMRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.ORCID http://orcid.org/0000-0002-1337-0612
Thomas MacartneyMRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.ORCID http://orcid.org/0000-0002-6745-183X
Constance AlabertMolecular Cell and Developmental Biology Division, School of Life Sciences, University of Dundee, Dundee, UK.
Chris P PontingMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Sophie E PoloLaboratory of Epigenome Integrity, Epigenetics and Cell Fate Centre, UMR 7216 CNRS - Université Paris Cité, Paris, France.ORCID http://orcid.org/0000-0003-4821-9354
Eric A MiskaGurdon Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-4450-576X
Anton GartnerIBS Centre for Genomic Integrity at Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea.
Julie AhringerGurdon Institute, University of Cambridge, Cambridge, UK.
John RouseMRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK. j.rouse@dundee.ac.uk.ORCID http://orcid.org/0000-0003-1183-8303
University of Cambridge · GBUniversity of Dundee · GBCentre National de la Recherche Scientifique · FRUlsan National Institute of Science and Technology · KRAgency for Science, Technology and Research · SGEuropean Bioinformatics Institute · GBInstitute of Genetics and Cancer · GBMRC Laboratory of Molecular Biology · GB

Funding

Cancer Research UK 27826European Research Council 818625Medical Research Council MC_U105192715Medical Research Council MC_UU_00007/15Medical Research Council MC_UU_00018/5Medical Research Council MR/S021620/1Wellcome Trust 217170
6 · The paper itself

Abstract

Histone chaperones control nucleosome density and chromatin structure. In yeast, the H3-H4 chaperone Spt2 controls histone deposition at active genes but its roles in metazoan chromatin structure and organismal physiology are not known. Here we identify the Caenorhabditis elegans ortholog of SPT2 (CeSPT-2) and show that its ability to bind histones H3-H4 is important for germline development and transgenerational epigenetic gene silencing, and that spt-2 null mutants display signatures of a global stress response. Genome-wide profiling showed that CeSPT-2 binds to a range of highly expressed genes, and we find that spt-2 mutants have increased chromatin accessibility at a subset of these loci. We also show that SPT2 influences chromatin structure and controls the levels of soluble and chromatin-bound H3.3 in human cells. Our work reveals roles for SPT2 in controlling chromatin structure and function in Metazoa.

Indexed as

DNA-Binding ProteinsHistone ChaperonesAnimalsChromatinHistonesHumansNucleosomesSaccharomyces cerevisiaeChromatinDNA-Binding ProteinsHistone ChaperonesHistonesNucleosomes

Identifiers

PMID38238586
PMCPMC7615752
OpenAlexW4390975431

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.