Evidence map›Paper›PMID 38239409›Full record

ArticleCritical care explorations2024

A Genome-Wide Association Study of Serum Metabolite Profiles in Septic Shock Patients.

Emily R Daubney, Shannon D'Urso, Gabriel Cuellar-Partida, Dorrilyn Rajbhandari, Elizabeth Peach, Erika de Guzman, Colin McArthur, Andrew Rhodes, Jason Meyer, Simon Finfer and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care explorations, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 3 countries.

Emily R DaubneyInstitute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia.
Shannon D'UrsoInstitute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia.
Gabriel Cuellar-PartidaFrazer Institute, University of Queensland, Brisbane, QLD, Australia.
Dorrilyn RajbhandariThe George Institute for Global Health, Sydney, NSW, Australia.
Elizabeth PeachFrazer Institute, University of Queensland, Brisbane, QLD, Australia.
Erika de GuzmanAustralian Translational Genomics Centre, Queensland University of Technology, Brisbane, QLD, Australia.
Colin McArthurDepartment of Critical Care Medicine, Auckland City Hospital, Auckland, New Zealand.
Andrew RhodesDepartment of Adult Critical Care, St George's University Hospitals NHS Foundation Trust and St George's University of London, London, United Kingdom.
Jason MeyerThe George Institute for Global Health, Sydney, NSW, Australia.
Simon FinferThe George Institute for Global Health, Sydney, NSW, Australia.
John MyburghThe George Institute for Global Health, Sydney, NSW, Australia.
Jeremy CohenRoyal Brisbane and Women's Hospital, Brisbane, QLD, Australia.
Horst Joachim SchirraCentre for Advanced Imaging, The University of Queensland, Brisbane, QLD, Australia.
Balasubramanian VenkateshThe George Institute for Global Health, Sydney, NSW, Australia.
David M EvansInstitute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia.
The University of Queensland · AUThe George Institute for Global Health · AUAuckland City Hospital · NZGriffith University · AUImperial College London · GBPrincess Alexandra Hospital · AUTranslational Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe sought to assess whether genetic associations with metabolite concentrations in septic shock patients could be used to identify pathways of potential importance for understanding sepsis pathophysiology.

designRetrospective multicenter cohort studies of septic shock patients.

settingAll participants who were admitted to 27 participating hospital sites in three countries (Australia, New Zealand, and the United Kingdom) were eligible for inclusion. PATIENTS: Adult, critically ill, mechanically ventilated patients with septic shock (

interventionsNone. MEASUREMENTS AND MAIN

resultsA genome-wide association study was conducted for a range of serum metabolite levels for participants. Genome-wide significant associations (

conclusionsWe suggest that the genetic associations with metabolites may reflect a starvation response rather than processes involved in sepsis pathophysiology. However, our results require further investigation and replication in both healthy and diseased cohorts including those of different ancestry.

Indexed as

geneticsmetabolomicsmolecular biologysepsis

Identifiers

PMID38239409
PMCPMC10796137
OpenAlexW4390938350

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.