ArticleBMC public health2024
Metabolic syndrome increases osteoarthritis risk: findings from the UK Biobank prospective cohort study.
Article in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05670314 (Molecular Signatures of Endocannabinoid Induced Pain Relief in Humans), which is not on this map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Molecular Signatures of Endocannabinoid Induced Pain Relief in Humans: Lifestyle Interventions, Systemic and Localised Changes
Who cites it
32 citing papers in PubMed, 40 citations in OpenAlex.
- Tackling obesity's impact: the need to address metabolic syndrome in osteoarthritis management.Future science OA · 2026Article
- Endocrine‑metabolic imbalance drives osteoarthritis: From whole‑joint pathobiology to precision therapy (Review).International journal of molecular medicine · 2026Review
- Studying the Natural History of the Knee Joint.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026Review
- Association of metformin with osteoarthritis progression and total joint arthroplasty: evidence from the UK Biobank, a large population-based cohort study.Clinical rheumatology · 2026Article
- Article
- Longitudinal multicohort evidence for bidirectional diabetes arthritis links in older adults.iScience · 2026Article
- Joint associations of chronic heat exposure and physical activity with the risk of knee osteoarthritis: a prospective cohort study based on the UK biobank.BMC public health · 2026Article
- Metabolic dysfunction-associated fatty liver disease and risk of knee osteoarthritis: A prospective cohort study.Clinical and experimental medicine · 2026Article
- The association between social determinants, lifestyle, and metabolic factors and the incidence of hand osteoarthritis: A cohort study of British adults.Clinical rheumatology · 2026Article
- The role of metabolic syndrome in osteoarthritis development: Is obesity the key driver?Osteoarthritis and cartilage open · 2026Article
- Weight loss ameliorates symptoms of osteoarthritis and is correlated with alterations in soluble bone and cartilage markers: an analysis of patient-reported outcomes and biomarkers.BMC rheumatology · 2026Article
- Does metabolically healthy obesity increase the risk of knee and hand osteoarthritis? A population-based cohort study.BMC musculoskeletal disorders · 2026Article
- Immunonutritional biomarkers in osteoarthritis: mechanistic insights and prognostic potential.Frontiers in immunology · 2026Review
- Metabolic syndrome and knee osteoarthritis: associations with disease stage and pain.Rheumatology advances in practice · 2026Article
- Association of High-Sensitivity C-Reactive Protein with Metabolic Syndrome and Transitions in Metabolic Status: A Combined Cross-Sectional and Cohort Study with Gender Differences in Chinese Adults.Journal of inflammation research · 2026Article
- Unraveling the connection between obesity, metabolic syndrome and osteoarthritis risk: a large-observational study.Diabetology & metabolic syndrome · 2025Article
- Causal inference study on the effect of exogenous insulin on the risk of osteoarthritis.Medicine · 2025Article
- Intake of one-carbon metabolism nutrients and risk of rheumatoid arthritis: a prospective UK biobank cohort study.European journal of nutrition · 2025Article
- Correlation of radiographic and histopathological changes with IL-17 and advanced oxidation protein products in knee osteoarthritic individuals with metabolic syndrome.Innovative surgical sciences · 2025Article
- The role of the infrapatellar fat pad in osteoporotic knee osteoarthritis: bone-fat crosstalk: cross-sectional studies.Journal of orthopaedic surgery and research · 2025Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveThe association between Metabolic Syndrome (MetS), its components, and the risk of osteoarthritis (OA) has been a topic of conflicting evidence in different studies. The aim of this present study is to investigate the association between MetS, its components, and the risk of OA using data from the UK Biobank.
methodsA prospective cohort study was conducted in the UK Biobank to assess the risk of osteoarthritis (OA) related to MetS. MetS was defined according to the criteria set by the International Diabetes Federation (IDF). Additionally, lifestyle factors, medications, and the inflammatory marker C-reactive protein (CRP) were included in the model. Cox proportional hazards regression was used to calculate hazard ratios (HR) and 95% confidence intervals (CI). The cumulative risk of OA was analyzed using Kaplan-Meier curves and log-rank tests. To explore potential nonlinear associations between MetS components and OA risk, a restricted cubic splines (RCS) model was employed. In addition, the polygenic risk score (PRS) of OA was calculated to characterize individual genetic risk.
resultsA total of 45,581 cases of OA were identified among 370,311 participants, with a median follow-up time of 12.48 years. The study found that individuals with MetS had a 15% higher risk of developing OA (HR = 1.15, 95%CI:1.12-1.19). Additionally, central obesity was associated with a 58% increased risk of OA (HR = 1.58, 95%CI:1.5-1.66), while hyperglycemia was linked to a 13% higher risk (HR = 1.13, 95%CI:1.1-1.15). Dyslipidemia, specifically in triglycerides (HR = 1.07, 95%CI:1.05-1.09) and high-density lipoprotein (HR = 1.05, 95%CI:1.02-1.07), was also found to be slightly associated with OA risk. When stratified by PRS, those in the high PRS group had a significantly higher risk of OA compared to those with a low PRS, whereas no interaction was found between MetS and PRS on OA risks. Furthermore, the presence of MetS significantly increased the risk of OA by up to 35% in individuals with elevated CRP levels (HR = 1.35, 95% CI:1.3-1.4).
conclusionMetS and its components have been found to be associated with an increased risk of OA, particularly in individuals with elevated levels of CRP. These findings highlight the significance of managing MetS as a preventive and intervention measure for OA.
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