ArticleMolecular plant2024
Lipid phosphorylation by a diacylglycerol kinase suppresses ABA biosynthesis to regulate plant stress responses.
Article in Molecular plant, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- A phosphatidic acid-based retrograde signaling pathway responsive to abiotic stress in Arabidopsis.The Plant journal : for cell and molecular biology · 2026Article
- Mechanisms and Advances in Plant Lipid Regulatory Responses Under Biotic and Abiotic Stress.Genes · 2026Review
- Holistic overview of regulatory networks governing seed dormancy and germination in plants.Science China. Life sciences · 2026Review
- PHR1-like 7 and phosphatidic acid oppositely regulate TAG degradation and seed oil accumulation in Arabidopsis.Plant communications · 2026Article
- Overexpression and silencing of the cottonFrontiers in plant science · 2026Article
- Bio-stimulants enhance cold tolerance in tobacco through antioxidant defense and photosynthetic regulation.Frontiers in microbiology · 2026Review
- CDP-DAG synthases regulate plant growth and broad-spectrum disease resistance.Plant signaling & behavior · 2025Article
- Integrated lipidomics and physiological analyses reveal the critical role of leaf sheath wax remodeling in wheat (Triticum aestivum L.) drought resistance.BMC plant biology · 2025Article
- Lipid-sugar conversion regulates early white clover (Trifolium repens) seedling establishment under cadmium stress.Planta · 2025Article
- OsWNK9 regulates the expression of key transcription factors, phytohormonal, and transporters genes to improve salinity stress tolerance in rice.Scientific reports · 2025Article
- Unveiling the regulatory role of GRP7 in ABA signal-mediated mRNA translation efficiency regulation.Nature communications · 2025Article
- Review
- Phosphatidic acid signaling in modulating plant reproduction and architecture.Plant communications · 2025Review
- Exploring the Genetic Basis of Drought Tolerance inInternational journal of molecular sciences · 2024Article
- miRNA Sequencing Analysis in Maize Roots Treated with Neutral and Alkaline Salts.Current issues in molecular biology · 2024Article
- Fine-tuning phosphatidic acid production for optimal plant stress responses.Trends in biochemical sciences · 2024Review
- OsWNK9 mitigates salt stress by promoting root growth and stomatal closure in rice.Physiologia plantarumArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Lipid phosphorylation by diacylglycerol kinase (DGK) that produces phosphatidic acid (PA) plays important roles in various biological processes, including stress responses, but the underlying mechanisms remain elusive. Here, we show that DGK5 and its lipid product PA suppress ABA biosynthesis by interacting with ABA-DEFICIENT 2 (ABA2), a key ABA biosynthesis enzyme, to negatively modulate plant response to abiotic stress tested in Arabidopsis thaliana. Loss of DGK5 function rendered plants less damaged, whereas overexpression (OE) of DGK5 enhanced plant damage to water and salt stress. The dgk5 mutant plants exhibited decreased total cellular and nuclear levels of PA with increased levels of diacylglycerol, whereas DGK5-OE plants displayed the opposite effect. Interestingly, we found that both DGK5 and PA bind to the ABA-synthesizing enzyme ABA2 and suppress its enzymatic activity. Consistently, the dgk5 mutant plants exhibited increased levels of ABA, while DGK5-OE plants showed reduced ABA levels. In addition, we showed that both DGK5 and ABA2 are detected in and outside the nuclei, and loss of DGK5 function decreased the nuclear association of ABA2. We found that both DGK5 activity and PA promote nuclear association of ABA2. Taken together, these results indicate that both DGK5 and PA interact with ABA2 to inhibit its enzymatic activity and promote its nuclear sequestration, thereby suppressing ABA production in response to abiotic stress. Our study reveals a sophisticated mechanism by which DGK5 and PA regulate plant stress responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.