ArticleAlzheimer's research & therapy2024
Multi-omics and pathway analyses of genome-wide associations implicate regulation and immunity in verbal declarative memory performance.
Open access · goldAbstract read
In one paragraph
Article in Alzheimer's research & therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- Effects of BACE2 polymorphisms on verbal memory in the general population.European archives of psychiatry and clinical neuroscience · 2026Article
- Biomarkers of cognitive and memory decline in psychotropic drug users.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- The ROSMAP project: aging and neurodegenerative diseases through omic sciences.Frontiers in neuroinformatics · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
67 authors at 20 institutions in 10 countries.
Hao MeiDepartment of Data Science, John D. Bower School of Population Health, University of Mississippi Medical Center, Jackson, MS, USA. hmei@umc.edu.
Jeannette SiminoDepartment of Data Science, John D. Bower School of Population Health, University of Mississippi Medical Center, Jackson, MS, USA. jsimino@umc.edu.
Lianna LiDepartment of Biology, Tougaloo College, Jackson, MS, USA.
Fan JiangShanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Joshua C BisDepartment of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
Gail DaviesDepartment of Psychology, Lothian Birth Cohorts Group, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
W David HillDepartment of Psychology, Lothian Birth Cohorts Group, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
Charley XiaDepartment of Psychology, Lothian Birth Cohorts Group, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.
Qiong YangDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Jari LahtiTurku Institute for Advanced Research, University of Turku, Turku, Finland.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Mirna KirinWork completed while at The University of Edinburgh, Edinburgh, UK.
Philip De JagerTaub Institute for Research On Alzheimer's Disease and the Aging Brain, Columbia Irving University Medical Center, New York, NY, USA.
Nicola J ArmstrongMathematics and Statistics, Curtin University, Perth, Australia.
Mohsen GhanbariDepartment of Epidemiology, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands.
Ivana KolcicSchool of Medicine, University of Split, Split, Croatia.
Christopher MoranDepartment of Geriatric Medicine, Frankston Hospital, Peninsula Health, Melbourne, Australia.
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Murali SargurupremrajInserm, Bordeaux Population Health Research Center, Team VINTAGE, UMR 1219, University of Bordeaux, Bordeaux, France.
Shamsed MahmudDepartment of Data Science, John D. Bower School of Population Health, University of Mississippi Medical Center, Jackson, MS, USA.
Myriam FornageThe Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Claudia L SatizabalThe University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Ozren PolasekSchool of Medicine, University of Split, Split, Croatia.
Katri RäikkönenDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
David C LiewaldDepartment of Psychology, Lothian Birth Cohorts Group, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
Georg HomuthInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Michele CallisayaPeninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia.
Karen A MatherCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.
B Gwen WindhamGertrude C. Ford Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, MS, USA.
Tatijana ZemunikSchool of Medicine, University of Split, Split, Croatia.
Aarno PalotieDepartment of Medicine, Department of Neurology and Department of Psychiatry, Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Alison PattieDepartment of Psychology, Lothian Birth Cohorts Group, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
Sandra van der AuweraDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Anbupalam ThalamuthuCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.
David S KnopmanDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Igor RudanCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
John M StarrDepartment of Psychology, Lothian Birth Cohorts Group, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
Katharina WittfeldDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Nicole A KochanCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.
Michael E GriswoldGertrude C. Ford Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, MS, USA.
Veronique VitartMedical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Henry BrodatyCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.
Rebecca GottesmanStroke, Cognition, and Neuroepidemiology (SCAN) Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Simon R CoxDepartment of Psychology, Lothian Birth Cohorts Group, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
Bruce M PsatyDepartment of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
Eric BoerwinkleHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
Daniel I ChasmanHarvard Medical School, Boston, MA, USA.
Francine GrodsteinDepartment of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Perminder S SachdevCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.
Velandai SrikanthDepartment of Geriatric Medicine, Frankston Hospital, Peninsula Health, Melbourne, Australia.
Caroline HaywardMedical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
James F WilsonCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
Johan G ErikssonDepartment of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Hans J GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
M Arfan IkramDepartment of Epidemiology, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands.
Ian J DearyDepartment of Psychology, Lothian Birth Cohorts Group, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
Cornelia M van DuijnNuffield Department of Population Health, Medical Sciences Division, University of Oxford, Oxford, UK.
Lenore LaunerLaboratory of Epidemiology and Population Sciences, National Institute On Aging, Bethesda, MD, USA.
Annette L FitzpatrickDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Sudha SeshadriThe National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.
Jan BresslerHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
Stephanie DebetteInserm, Bordeaux Population Health Research Center, Team VINTAGE, UMR 1219, University of Bordeaux, Bordeaux, France.
Thomas H MosleyGertrude C. Ford Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, MS, USA.
University of Edinburgh · GBUniversitätsmedizin Greifswald · DEUniversity of Mississippi Medical Center · USUNSW Sydney · AUUniversity of Michigan–Ann Arbor · USBordeaux Population Health · FRBrigham and Women's Hospital · USErasmus MC · NLFrankston Hospital · AUThe University of Texas Health Science Center at Houston · USUniversity of Split · HRUniversity of Washington · USAlgebra University College · HRAlzheimer Scotland · GBBrown Foundation · USColumbia University Irving Medical Center · USCurtin University · AUFinnish Institute for Health and Welfare · FIFramingham Heart Study · USInstitute for Neurodegenerative Disorders · US
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MStatistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, TAMIMI, RULLA M · 2000 to 2019
$77.8MInstitute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MSUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1MEPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3MTREATMENT OF DEPRESSION IN ALZHEIMER'S DISEASEP50AG005133 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SWEET, ROBERT A · 1985 to 2019
$43.0MValidity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI WILLETT, WALTER C. · 1991 to 2009
$41.8MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4MRisk Factors for Breast Cancer in Younger NursesR01CA050385 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 1989 to 2019
$32.3MWomen's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2MSouth Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Sudha Seshadri · 2021 to 2026
$24.0MMedical Research Council MC_UU_00007/10Medical Research Council MR/K026992/1Medical Research Council MR/T030852/1NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001881NCI NIH HHS P01 CA055075NCI NIH HHS P01 CA087969NCI NIH HHS R01 CA047988NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA050385NCI NIH HHS R01 CA065725NCI NIH HHS R01 CA067262NCI NIH HHS R01 CA134958NCI NIH HHS U01 CA049449NCI NIH HHS U01 CA067262NCI NIH HHS U01 CA098233NCI NIH HHS UM1 CA182913NCRR NIH HHS UL1 RR025005NEI NIH HHS R01 EY009611NEI NIH HHS R01 EY015473NHGRI NIH HHS U01 HG004399NHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01 HG004728NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS R01 HL034594NHLBI NIH HHS R01 HL035464NHLBI NIH HHS R01 HL043851NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL070825NHLBI NIH HHS R01 HL071917NHLBI NIH HHS R01 HL080467NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL087660NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL119443NHLBI NIH HHS R01 HL120393NHLBI NIH HHS U01 HL054457NHLBI NIH HHS U01 HL054464NHLBI NIH HHS U01 HL054481NHLBI NIH HHS U01 HL080295NIA NIH HHS K08 AG034290NIA NIH HHS K25 AG041906NIA NIH HHS N01 AG012100NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG066546NIA NIH HHS P50 AG005133NIA NIH HHS R01 AG008122NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG016495NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG020098NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG030146NIA NIH HHS R01 AG031287NIA NIH HHS R01 AG033193NIDDK NIH HHS P01 DK070756NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK058845NIGMS NIH HHS 1P20GM144041NIGMS NIH HHS P20 GM144041NIH HHS R01HL105756NINDS NIH HHS R01 NS017950NINDS NIH HHS R01 NS041558
Abstract
backgroundUncovering the functional relevance underlying verbal declarative memory (VDM) genome-wide association study (GWAS) results may facilitate the development of interventions to reduce age-related memory decline and dementia.
methodsWe performed multi-omics and pathway enrichment analyses of paragraph (PAR-dr) and word list (WL-dr) delayed recall GWAS from 29,076 older non-demented individuals of European descent. We assessed the relationship between single-variant associations and expression quantitative trait loci (eQTLs) in 44 tissues and methylation quantitative trait loci (meQTLs) in the hippocampus. We determined the relationship between gene associations and transcript levels in 53 tissues, annotation as immune genes, and regulation by transcription factors (TFs) and microRNAs. To identify significant pathways, gene set enrichment was tested in each cohort and meta-analyzed across cohorts. Analyses of differential expression in brain tissues were conducted for pathway component genes.
resultsThe single-variant associations of VDM showed significant linkage disequilibrium (LD) with eQTLs across all tissues and meQTLs within the hippocampus. Stronger WL-dr gene associations correlated with reduced expression in four brain tissues, including the hippocampus. More robust PAR-dr and/or WL-dr gene associations were intricately linked with immunity and were influenced by 31 TFs and 2 microRNAs. Six pathways, including type I diabetes, exhibited significant associations with both PAR-dr and WL-dr. These pathways included fifteen MHC genes intricately linked to VDM performance, showing diverse expression patterns based on cognitive status in brain tissues.
conclusionsVDM genetic associations influence expression regulation via eQTLs and meQTLs. The involvement of TFs, microRNAs, MHC genes, and immune-related pathways contributes to VDM performance in older individuals.
Indexed as
Genome-Wide Association StudyMicroRNAsAgedCognitionHumansMemoryMultiomicsPolymorphism, Single NucleotideMicroRNAsDelayed recallExpressionGenome-wide association studyImmunityMemoryMulti-omics
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.