ArticleFrontiers in pediatrics2023
FIB-4 and APRI scores for progressive liver fibrosis diagnosis in children with biliary atresia.
Article in Frontiers in pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Echocardiographic Evaluation of Systolic and Diastolic Cardiac Functions in Pediatric Cirrhosis: Unmasking Subclinical Alterations and Correlation with Liver Severity Scores.Children (Basel, Switzerland) · 2026Article
- Assessment of hepatic fibrosis in Egyptian children and adolescents with beta thalassemia major: a single center study.European journal of pediatrics · 2026Article
- Short-Term Outcome of Infants with Biliary Artesia Following Kasai Portoenterostomy.Indian journal of pediatrics · 2026Article
- Biliary atresia-related liver fibrosis.Frontiers in cell and developmental biology · 2026Review
- The value of MMP-7 combined with serological markers in diagnosing liver fibrosis in children with biliary atresia.BMC pediatrics · 2025Article
- Application of machine learning in constructing a diagnostic model for neonatal biliary atresia.Pediatric investigation · 2025Article
- The predictive value of the aspartate aminotransferase to platelet ratio index combined with liver biochemical indexes for 2 years native liver survival in patients with biliary atresia.Pediatric surgery international · 2025Article
- Relationship between dietary inflammatory index and metabolic dysfunction associated steatotic liver disease in children.Scientific reports · 2025Article
- Ultrasound reliability for biliary atresia diagnoses in children: a single-center study.Qatar medical journal · 2025Article
- The timing of minimally invasive surgery for prenatally diagnosed choledochal cysts.BMC pediatrics · 2024Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Finding non-invasive methods to predict the degree of liver fibrosis is very important in managing children with biliary atresia. Therefore, we explored the predictive value of APRI, FIB-4, and serological markers for liver fibrosis in children with biliary atresia. Methods: This study retrospectively reviewed data from children diagnosed with BA between March and December 2022. Liver tissue pathology specimens were obtained during surgery. The serum markers were measured within 2 days before the Kasai procedure or liver transplantation. The aspartate aminotransferase-to-platelet ratio index (APRI) and the four-factor-based fibrosis index (FIB-4) were calculated. The outcome was the diagnosis of progressive liver fibrosis. Results: This study reviewed the data from 41 children with biliary atresia. APRI had 52% sensitivity and 83% specificity for progressive liver fibrosis, while FIB-4 had 83% sensitivity and 67% specificity. Their areas under the curve were not significantly different from those of conventional markers. Conclusion: Although they were not better than conventional markers, APRI and FIB-4 can be used as follow-up markers for progressive liver fibrosis in patients with biliary atresia, but their predictive value was moderate. Additional studies are necessary to determine whether they could be combined with other markers to improve their predictive value.
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