Evidence map›Paper›PMID 38252107›Full record

Trial reportEuropean heart journal2024

Icosapent ethyl following acute coronary syndrome: the REDUCE-IT trial.

Neila Sayah, Deepak L Bhatt, Michael Miller, Eliot A Brinton, Terry A Jacobson, Steven B Ketchum, Lixia Jiao, Armando Lira Pineda, Ralph T Doyle, Jean Claude Tardif and 2 more

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in European heart journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07762755 (A Randomized Controlled Trial Evaluating the Effect of Icosapent Ethyl on High-Risk Coronary Plaques Using 18F-Sodium Fluoride PET/CT), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07762755 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Randomized Controlled Trial Evaluating the Effect of Icosapent Ethyl on High-Risk Coronary Plaques Using 18F-Sodium Fluoride PET/CT

TypeinterventionalSponsorChina National Center for Cardiovascular DiseasesRan2026 to 2029Enrolled100ConditionsCoronary Artery Disease, Hyperlipidaemia, Hypertriglyceridaemia, Coronary AtherosclerosisArmsicosapent ethyl (IPE), Standard LDL-C-Lowering Therapy
3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Neila SayahDepartment of Cardiology, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, 46 Rue Henri Huchard, 75018 Paris, France.ORCID 0009-0009-0473-9623
Deepak L BhattMount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai Health, New York, NY, USA.ORCID 0000-0002-1278-6245
Michael MillerDepartment of Medicine, Crescenz Veterans Affairs Medical Center and University of Pennsylvania School of Medicine, Philadelphia, PA, USA.ORCID 0000-0002-1679-2095
Eliot A BrintonUtah Lipid Center, Salt Lake City, UT, USA.ORCID 0000-0002-9807-4010
Terry A JacobsonLipid Clinic and Cardiovascular Risk Reduction Program, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-9926-2179
Steven B KetchumAmarin Pharma, Inc. (Amarin), Bridgewater, NJ, USA.ORCID 0000-0002-9302-4743
Lixia JiaoAmarin Pharma, Inc. (Amarin), Bridgewater, NJ, USA.ORCID 0000-0001-7003-4925
Armando Lira PinedaAmarin Pharma, Inc. (Amarin), Bridgewater, NJ, USA.ORCID 0000-0002-1746-3162
Ralph T DoyleAmarin Pharma, Inc. (Amarin), Bridgewater, NJ, USA.ORCID 0000-0003-4068-7778
Jean Claude TardifMontreal Heart Institute, Université de Montréal, Montreal, Québec, Canada.ORCID 0000-0002-8200-8983
Christie M BallantyneDepartment of Medicine, Baylor College of Medicine, and the Texas Heart Institute, Houston, TX, USA.ORCID 0000-0002-6432-1730
Ph Gabriel StegDepartment of Cardiology, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, 46 Rue Henri Huchard, 75018 Paris, France.ORCID 0000-0001-6896-2941

Funding

Amarin PharmaSteering Committee
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Acute Coronary SyndromeCardiovascular DiseasesEicosapentaenoic AcidHydroxymethylglutaryl-CoA Reductase InhibitorsHypertriglyceridemiaHumansTriglyceridesEicosapentaenoic Acideicosapentaenoic acid ethyl esterHydroxymethylglutaryl-CoA Reductase InhibitorsTriglyceridesAcute coronary syndromeClinical trialsIcosapent ethylIschaemic events

Identifiers

PMID38252107
PMCPMC10984562

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.