Evidence map›Paper›PMID 38256199›Full record

ArticleInternational journal of molecular sciences2024

Maternal Diet High in Linoleic Acid Alters Offspring Lipids and Hepatic Regulators of Lipid Metabolism in an Adolescent Rat Model.

Nirajan Shrestha, Simone L Sleep, Olivia J Holland, Josif Vidimce, Andrew C Bulmer, James S M Cuffe, Anthony V Perkins, Andrew J McAinch, Deanne H Hryciw

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
5.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Nirajan ShresthaSchool of Pharmacy and Medical Science, Griffith University, Southport, QLD 4222, Australia.ORCID 0000-0003-1259-0661
Simone L SleepSchool of Pharmacy and Medical Science, Griffith University, Southport, QLD 4222, Australia.ORCID 0000-0003-1654-8532
Olivia J HollandSchool of Pharmacy and Medical Science, Griffith University, Southport, QLD 4222, Australia.ORCID 0000-0002-5798-5264
Josif VidimceSchool of Pharmacy and Medical Science, Griffith University, Southport, QLD 4222, Australia.
Andrew C BulmerSchool of Pharmacy and Medical Science, Griffith University, Southport, QLD 4222, Australia.
James S M CuffeSchool of Biomedical Sciences, The University of Queensland, St Lucia, QLD 4072, Australia.ORCID 0000-0002-2675-8149
Anthony V PerkinsSchool of Pharmacy and Medical Science, Griffith University, Southport, QLD 4222, Australia.ORCID 0000-0002-9829-6772
Andrew J McAinchInstitute for Health and Sport, Victoria University, Melbourne, VIC 3001, Australia.ORCID 0000-0002-8762-4865
Deanne H HryciwInstitute for Health and Sport, Victoria University, Melbourne, VIC 3001, Australia.ORCID 0000-0003-1697-8890
Griffith University · AUAustralian Institute for Musculoskeletal Science · AUThe University of Queensland · AU

Funding

Allen Foundation Unknown
6 · The paper itself

Abstract

Linoleic acid (LA), an n-6 polyunsaturated fatty acid (PUFA), is essential for fetal growth and development. A maternal high LA (HLA) diet alters cardiovascular development in adolescent rats and hepatic function in adult rats in a sex-specific manner. We investigated the effects of an HLA diet on adolescent offspring hepatic lipids and hepatic lipid metabolism gene expression, and the ability of the postnatal diet to alter these effects. Female Wistar Kyoto rats were fed low LA (LLA; 1.44% energy from LA) or high LA (HLA; 6.21% energy from LA) diets during pregnancy and gestation/lactation. Offspring, weaned at postnatal day (PN) 25, were fed LLA or HLA and euthanised at PN40 (

Indexed as

Linoleic AcidLipid MetabolismAnimalsDietFatty Acids, Omega-6FemaleLiverMalePPAR gammaPregnancyRatsRats, Inbred WKYFatty Acids, Omega-6Linoleic AcidPPAR gammalinoleic acidmaternaloffspringsex-specific liver

Identifiers

PMID38256199
PMCPMC10816089
OpenAlexW4390948287

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.