Evidence map›Paper›PMID 38256206›Full record

Trial reportInternational journal of molecular sciences2024

Modulation of miR-29a and miR-29b Expression and Their Target Genes Related to Inflammation and Renal Fibrosis by an Oral Nutritional Supplement with Probiotics in Malnourished Hemodialysis Patients.

Corina Verónica Sasso, Said Lhamyani, Francisco Hevilla, Marina Padial, María Blanca, Guillermina Barril, Tamara Jiménez-Salcedo, Enrique Sanz Martínez, Ángel Nogueira, Ana María Lago-Sampedro and 1 more

Open access · goldAbstract readRandomized Controlled TrialMulticenter Study
In one paragraph

Trial report in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Dietary Intake and Gut Microbiome in CKD.Clinical journal of the American Society of Nephrology : CJASN · 2025
    Review
  7. Investigating circulating expression profile forFrontiers in molecular biosciences · 2025
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Corina Verónica SassoServicio de Endocrinología y Nutrición, Hospital Regional Universitario de Málaga, 29009 Málaga, Spain.
Said LhamyaniServicio de Endocrinología y Nutrición, Hospital Regional Universitario de Málaga, 29009 Málaga, Spain.ORCID 0000-0002-9830-9772
Francisco HevillaServicio de Endocrinología y Nutrición, Hospital Regional Universitario de Málaga, 29009 Málaga, Spain.
Marina PadialServicio de Endocrinología y Nutrición, Hospital Regional Universitario de Málaga, 29009 Málaga, Spain.
María BlancaServicio de Endocrinología y Nutrición, Hospital Universitario Rey Juan Carlos, 28933 Madrid, Spain.
Guillermina BarrilServicio de Nefrología, Hospital de la Princesa, 28006 Madrid, Spain.ORCID 0000-0003-4067-634X
Tamara Jiménez-SalcedoServicio de Nefrología, Hospital Regional Universitario, 29010 Málaga, Spain.
Enrique Sanz MartínezServicio de Endocrinología y Nutrición, Hospital Universitario Rey Juan Carlos, 28933 Madrid, Spain.
Ángel NogueiraServicio de Nefrología, Hospital de la Princesa, 28006 Madrid, Spain.
Ana María Lago-SampedroServicio de Endocrinología y Nutrición, Hospital Regional Universitario de Málaga, 29009 Málaga, Spain.ORCID 0000-0002-3072-9981
Gabriel OlveiraServicio de Endocrinología y Nutrición, Hospital Regional Universitario de Málaga, 29009 Málaga, Spain.ORCID 0000-0002-7646-2899
Hospital Regional Universitario de Málaga · ESInstituto de Salud Carlos III · ESHospital Universitario de La Princesa · ESHospital Universitario Rey Juan Carlos · ES

Funding

Instituto de Salud Carlos III PI18/01041Ministerio de Ciencia e Innovación RTC-2017-5959-1
6 · The paper itself

Abstract

Malnutrition is prevalent in patients with chronic kidney disease (CKD), especially those on hemodialysis. Recently, our group described that a new oral nutritional supplement (ONS), specifically designed for malnourished (or at risk) hemodialysis patients with a "similar to the Mediterranean diet" pattern, improved caloric-protein intake, nutritional status and biomarkers of inflammation and oxidation. Our aim in this study was to evaluate whether the new ONS, associated with probiotics or not, may produce changes in miRNA's expression and its target genes in malnourished hemodialysis patients, compared to individualized diet recommendations. We performed a randomized, multicenter, parallel-group trial in malnourished hemodialysis patients with three groups (1: control (C) individualized diet (

Indexed as

Kidney DiseasesMalnutritionMicroRNAsProbioticsFibrosisHumansInflammationRenal DialysisMicroRNAsMIRN29a microRNA, humanMIRN29B1 microRNA, humanchronic kidney diseasecirculating miRNAsgene expressionhemodialysisinflammationmalnutritionoral nutritional supplementprobioticsrenal fibrosis

Identifiers

PMID38256206
PMCPMC10816158
OpenAlexW4390945827

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.