Evidence map›Paper›PMID 38256268›Full record

ReviewInternational journal of molecular sciences2024

Cancer Nano-Immunotherapy: The Novel and Promising Weapon to Fight Cancer.

Daniel J García-Domínguez, Soledad López-Enríquez, Gonzalo Alba, Carmen Garnacho, Carlos Jiménez-Cortegana, Rocío Flores-Campos, Luis de la Cruz-Merino, Nabil Hajji, Víctor Sánchez-Margalet, Lourdes Hontecillas-Prieto

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Nanocarriers for cutting-edge cancer immunotherapies.Journal of translational medicine · 2025
    Review
  7. Review
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Daniel J García-DomínguezDepartment of Medical Biochemistry and Molecular Biology, and Immunology, School of Medicine, University of Seville, 41009 Seville, Spain.ORCID 0000-0001-8150-2747
Soledad López-EnríquezDepartment of Medical Biochemistry and Molecular Biology, and Immunology, School of Medicine, University of Seville, 41009 Seville, Spain.ORCID 0000-0003-3727-1843
Gonzalo AlbaDepartment of Medical Biochemistry and Molecular Biology, and Immunology, School of Medicine, University of Seville, 41009 Seville, Spain.ORCID 0000-0002-6598-2039
Carmen GarnachoDepartment of Normal and Pathological Cytology and Histology, School of Medicine, University of Seville, 41009 Seville, Spain.ORCID 0000-0003-3399-0963
Carlos Jiménez-CorteganaDepartment of Medical Biochemistry and Molecular Biology, and Immunology, School of Medicine, University of Seville, 41009 Seville, Spain.ORCID 0000-0001-6956-7740
Rocío Flores-CamposDepartment of Medical Biochemistry and Molecular Biology, and Immunology, School of Medicine, University of Seville, 41009 Seville, Spain.
Luis de la Cruz-MerinoInstitute of Biomedicine of Seville, IBiS, 41013 Seville, Spain.
Nabil HajjiDepartment of Medical Biochemistry and Molecular Biology, and Immunology, School of Medicine, University of Seville, 41009 Seville, Spain.
Víctor Sánchez-MargaletDepartment of Medical Biochemistry and Molecular Biology, and Immunology, School of Medicine, University of Seville, 41009 Seville, Spain.ORCID 0000-0001-8638-8680
Lourdes Hontecillas-PrietoDepartment of Medical Biochemistry and Molecular Biology, and Immunology, School of Medicine, University of Seville, 41009 Seville, Spain.ORCID 0000-0002-0582-3386
Hospital Universitario Virgen Macarena · ESUniversidad de Sevilla · ESImperial College London · GBInstituto de Biomedicina de Sevilla · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer is a complex disease that, despite advances in treatment and the greater understanding of the tumor biology until today, continues to be a prevalent and lethal disease. Chemotherapy, radiotherapy, and surgery are the conventional treatments, which have increased the survival for cancer patients. However, the complexity of this disease together with the persistent problems due to tumor progression and recurrence, drug resistance, or side effects of therapy make it necessary to explore new strategies that address the challenges to obtain a positive response. One important point is that tumor cells can interact with the microenvironment, promoting proliferation, dissemination, and immune evasion. Therefore, immunotherapy has emerged as a novel therapy based on the modulation of the immune system for combating cancer, as reflected in the promising results both in preclinical studies and clinical trials obtained. In order to enhance the immune response, the combination of immunotherapy with nanoparticles has been conducted, improving the access of immune cells to the tumor, antigen presentation, as well as the induction of persistent immune responses. Therefore, nanomedicine holds an enormous potential to enhance the efficacy of cancer immunotherapy. Here, we review the most recent advances in specific molecular and cellular immunotherapy and in nano-immunotherapy against cancer in the light of the latest published preclinical studies and clinical trials.

Indexed as

ImmunotherapyNeoplasmsAntigen PresentationHumansImmune EvasionNanomedicineTumor Microenvironmentcancerclinical trialsimmunotherapynanomedicine

Identifiers

PMID38256268
PMCPMC10816838
OpenAlexW4390972196

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.