Evidence map›Paper›PMID 38257977›Full record

ArticleMicroorganisms2024

Increasing the Pentose Phosphate Pathway Flux to Improve Plasmid DNA Production in Engineered

Mitzi de la Cruz, Flavio Kunert, Hilal Taymaz-Nikerel, Juan-Carlos Sigala, Guillermo Gosset, Jochen Büchs, Alvaro R Lara

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 4 countries.

Mitzi de la CruzDepartamento de Procesos y Tecnología, Universidad Autónoma Metropolitana, Mexico City 05348, Mexico.
Flavio KunertChair of Biochemical Engineering (AVT.BioVT), RWTH Aachen University, 52074 Aachen, Germany.ORCID 0009-0008-9297-1854
Hilal Taymaz-NikerelDepartment of Genetics and Bioengineering, Istanbul Bilgi University, 34060 Istanbul, Turkey.ORCID 0000-0002-5523-263X
Juan-Carlos SigalaDepartamento de Procesos y Tecnología, Universidad Autónoma Metropolitana, Mexico City 05348, Mexico.
Guillermo GossetInstituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca 62210, Mexico.
Jochen BüchsChair of Biochemical Engineering (AVT.BioVT), RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0002-2012-3476
Alvaro R LaraDepartment of Biological and Chemical Engineering, Aarhus University, 8000 Aarhus, Denmark.ORCID 0000-0003-3535-7619
RWTH Aachen University · DEUniversidad Autónoma Metropolitana · MXAarhus University · DKIstanbul Bilgi University · TRUniversidad Nacional Autónoma de México · MX

Funding

Consejo Nacional de Humanidades, Ciencias y Tecnologías A1-S-8646
6 · The paper itself

Abstract

The demand of plasmid DNA (pDNA) as a key element for gene therapy products, as well as mRNA and DNA vaccines, is increasing together with the need for more efficient production processes. An engineered

Indexed as

glucose-glycerol co-utilizationpentose phosphate pathwayplasmid DNA vaccines

Identifiers

PMID38257977
PMCPMC10820320
OpenAlexW4390828721

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.