Evidence map›Paper›PMID 38259062›Full record

ArticlemSphere2024

Structural determination of

Hyojik Yang, Victoria I Verhoeve, Courtney E Chandler, Shreeram Nallar, Greg A Snyder, Robert K Ernst, Joseph J Gillespie

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. A critical role forProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Article
  3. PathogenicJournal of bacteriology · 2024
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hyojik Yang *Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, Maryland, USA.
Victoria I Verhoeve *Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Maryland, USA.
Courtney E ChandlerDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, Maryland, USA.
Shreeram NallarDivision of Vaccine Research, Institute of Human Virology, University of Maryland, Baltimore, Maryland, USA.
Greg A SnyderDepartment of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Maryland, USA.
Robert K ErnstDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, Maryland, USA.ORCID 0000-0001-5016-8694
Joseph J GillespieDepartment of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Maryland, USA.ORCID 0000-0002-5447-7264
University of Maryland, Baltimore · US

Funding

MS Diagnostic Bacterial Identification LibraryR01AI147314 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI ERNST, ROBERT K, GOODLETT, DAVID ROBINSON · 2020 to 2024
$2.3M
Investigating Rickettsia Interspecies and Host-Specific Lipopolysaccharide VariationR21AI166832 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI GILLESPIE, JOSEPH J · 2022 to 2023
$425k
Understanding the mechanism of 4-1BB costimulationR21AI052108 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI VELLA, ANTHONY T. · 2002 to 2002
$326k
NIAID NIH HHS R01 AI147314NIAID NIH HHS R21 AI052108NIAID NIH HHS R21 AI166832
6 · The paper itself

Abstract

Rickettsiae are Gram-negative obligate intracellular parasites of numerous eukaryotes. Human pathogens of the transitional group (TRG), typhus group (TG), and spotted fever group (SFG) rickettsiae infect blood-feeding arthropods, have dissimilar clinical manifestations, and possess unique genomic and morphological attributes. Lacking glycolysis, rickettsiae pilfer numerous metabolites from the host cytosol to synthesize peptidoglycan and lipopolysaccharide (LPS). For LPS, O-antigen immunogenicity varies between SFG and TG pathogens; however, lipid A proinflammatory potential is unknown. We previously demonstrated that

Indexed as

RickettsiaSpotted Fever Group RickettsiosisTyphus, Epidemic Louse-BorneHumansLipid ALipopolysaccharidesLipid ALipopolysaccharidesevolutionFLATnlipid AlipopolysaccharidepathogenesisRickettsiarickettsiosisRocky Mountain spotted feverspotted fever group

Identifiers

PMID38259062
PMCPMC10900879
OpenAlexW4391135881

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.