ArticleFrontiers in immunology2023
Association between dietary antioxidant levels and chronic obstructive pulmonary disease: a mediation analysis of inflammatory factors.
Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 45 citations in OpenAlex.
- Article
- Association Between Composite Dietary Antioxidant Index and Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome: Evidence From a Large Cohort in the UK Biobank.Food science & nutrition · 2026Article
- Inverse Association Between Composite Dietary Antioxidant Index and Prevalence of Pelvic Inflammatory Disease Among Women: A Cross-Sectional Study of NHANES 2013-2018.Healthcare (Basel, Switzerland) · 2026Article
- Relationship between the advanced lung cancer inflammation index (ALI) and all-cause and cause-specific mortality among patients with chronic obstructive pulmonary disease (COPD): a population-based study.BMC pulmonary medicine · 2026Article
- Evaluation of the antioxidant and anti-inflammatory efficacy of fermentedBiochemistry and biophysics reports · 2026Article
- Integrating multi-source data and machine learning to Decipher the psoriasis-COPD comorbidity.Clinical and experimental medicine · 2026Article
- The Sleep Connection: Exploring the Role of Composite Dietary Antioxidant Index in Sleep Quality Based on NHANES 2007-2014.International journal of medical sciences · 2026Article
- Nonlinear L-shaped association between composite dietary antioxidant index and risk of dementia: a prospective cohort study.Frontiers in public health · 2026Article
- Association between composite dietary antioxidant index and pulmonary function in middle-aged and older adults: results from two population-based studies.BMJ nutrition, prevention & health · 2026Article
- A Machine Learning-Derived Risk Score Based on Dietary Nutrient Intake for Early Detection and Prognostic Prediction of Preserved Ratio Impaired Spirometry.International journal of chronic obstructive pulmonary disease · 2026Article
- Associations of serum cotinine and dietary inflammatory and antioxidant profiles with appendicular skeletal muscle mass in US adults: A cross-sectional study of data from NHANES 2011-2018.Tobacco induced diseases · 2026Article
- Association Between Mefox and Prevalence of COPD: Evidence from NHANES 2011-2020.Healthcare (Basel, Switzerland) · 2025Article
- Association between carotene intake and hospital-acquired pneumonia in elderly men: a cross-sectional study.Aging clinical and experimental research · 2025Article
- Relationship of the oxidative balance score with the risk of frailty and mortality in patients with asthma: a mediation analysis of NHANES.BMC pulmonary medicine · 2025Article
- The Dietary Inflammatory Index (DII) and COPD: A Cross-Sectional Study from the NHANES.International journal of chronic obstructive pulmonary disease · 2025Article
- Composite dietary antioxidant index is associated with renal anemia: a cross-sectional study.International urology and nephrology · 2025Article
- Gender difference in the association between composite dietary antioxidant index and all-cause mortality.Frontiers in nutrition · 2025Article
- Association between compound dietary antioxidant index and all-cause and cancer mortality in patients with chronic obstructive pulmonary disease: results from NHANES 1999-2018.Frontiers in medicine · 2025Article
- Association Between Urinary Glyphosate Concentrations and Chronic Obstructive Pulmonary Disease in USA Participants: Evidence from NHANES 2013-2018.International journal of chronic obstructive pulmonary disease · 2025Article
- Association of dietary inflammatory index, composite dietary antioxidant index and risk of death among adult cancer survivors: findings from the National Health and Nutrition Examination Survey 2001-2018.Frontiers in immunology · 2025Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The development of chronic obstructive pulmonary disease (COPD) is strongly associated with oxidative stress, but it is unclear whether increasing dietary antioxidant intake reduces the risk of COPD. Therefore, this study assessed the association between antioxidant intake and COPD in US adults aged ≥ 40 years and further examined the correlation using the Composite Dietary Antioxidant Index (CDAI). Methods: The study included 8,257 US adults aged ≥ 40 years using data from the National Health and Nutrition Examination Survey (NHANES) for three cycles from 2007-2012. Multivariate logistic regression models were used to calculate the correlation between antioxidant intake and CDAI with COPD. Restricted cubic spline was further used to explore the exposure-response relationship. Mediation analysis was used to explore the role of inflammatory factors in the association between CDAI and COPD. Results: This study included 8257 participants (4111 women [weighted, 50.7%]; mean [SD] age, 58.8 [11.2] years). In a multivariable-adjusted model of single antioxidant intake, a linear downward association between carotenoid intake and the incidence of COPD (P for trend = 0.052; Pnon- linear = 0.961). In a multivariable adjusted model for CDAI, this association is similarly present (P for trend = 0.018; Pnon-linear = 0.360). Multiple linear regression modeling showed that leukocytes (P = 0.002), alkaline phosphatase (P< 0.001), and c-reactive protein (P< 0.001) were negatively associated with CDAI levels. Meanwhile, mediation analysis revealed that alkaline phosphatase and c-reactive protein partially influenced the association between CDAI and COPD prevalence, with mediation ratios of 6.4% (P< 0.01) and 4.68% (P = 0.04), respectively. Conclusion: The risk of COPD decreased with increased carotenoid intake and CDAI. In addition, CDAI has been found to be strongly associated with inflammatory factors and can reduce the incidence of COPD by mediating inflammatory factors.
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