ArticleFrontiers in endocrinology2023
A combined analysis of TyG index, SII index, and SIRI index: positive association with CHD risk and coronary atherosclerosis severity in patients with NAFLD.
Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47 citing papers in PubMed, 48 citations in OpenAlex.
- Diagnostic Value of Systemic Inflammatory Indices in Myocardial İnfarction With Non-Obstructive Coronary Arteries: Comparison With Obstructive Myocardial Infarction and Non-Critical Coronary Artery Disease.Cardiology research · 2026Article
- Development and validation of an interpretable machine learning model for predicting the risk of coronary heart disease risk in diabetes mellitus patients: a dual-center retrospective study.BMC medical informatics and decision making · 2026Article
- Combined lesion-specific pericoronary adipose tissue attenuation and triglyceride-glucose body mass index for improved risk stratification of major adverse cardiovascular events in patients with stable angina pectoris.Quantitative imaging in medicine and surgery · 2026Article
- Development and validation of a risk nomogram for predicting recurrence in patients with non-valvular atrial fibrillation after radiofrequency catheter ablation.BMC medical informatics and decision making · 2026Article
- Determinants of Liver Steatosis Progression in Chinese Children: A Prospective Cohort Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Triglyceride-glucose related index and its association with coronary heart disease risk in patients with metabolic dysfunction-associated steatotic liver disease: a retrospective analysis based on type 2 diabetes mellitus.Frontiers in endocrinology · 2026Article
- The Systemic Immune-Inflammation Index and High-Sensitivity C-Reactive Protein to High-Density Lipoprotein Cholesterol Ratio Predict Moderate and Severe Coronary Artery Stenosis in Older Patients with Coronary Heart Disease.Clinical interventions in aging · 2026Article
- Associations of Systemic Inflammatory Response Index (SIRI) and Systemic Inflammatory Index (SII) with Cerebral Atherosclerosis.Journal of inflammation research · 2026Article
- Systemic inflammatory response index: a novel predictor for cardiovascular disease risk in patients with primary biliary cholangitis.European journal of medical research · 2025Article
- Article
- The triglyceride-glucose index assesses mortality in patients with cerebral hemorrhage: a retrospective analysis based on a critical care medical database.BMC neurology · 2025Article
- Inflammatory indices AISI and SIRI in atherosclerosis risk stratification: validation across community and intensive care populations.Annals of medicine · 2025Article
- Predictive value of systemic inflammation response index for atherosclerotic cardiovascular disease risk in patients with hypercholesterolemia: a machine learning study with dual-cohort validation.Lipids in health and disease · 2025Article
- The effect of longitudinal trajectories of triglyceride-glucose index on the incident metabolic dysfunction-associated steatotic liver disease.BMC gastroenterology · 2025Article
- Association between the TyG index and MAFLD and its subtypes: a population-based cross-sectional study.BMC gastroenterology · 2025Article
- The relationship between liver stiffness, fat content measured by liver elastography, and coronary artery disease: a study based on the NHANES database.Scientific reports · 2025Article
- Interpretable machine learning analysis of immunoinflammatory biomarkers for predicting CHD among NAFLD patients.Cardiovascular diabetology · 2025Article
- Systemic immune-inflammatory index mediates the association between regular walking and depression in the elderly with coronary heart disease.BMC geriatrics · 2025Article
- Association between triglyceride-glucose index in early pregnancy and risk of preeclampsia: a multicenter retrospective cohort study.Lipids in health and disease · 2025Article
- Machine Learning-Based Immuno-Inflammatory Index Integrating Clinical Characteristics for Predicting Coronary Artery Plaque Rupture.Immunity, inflammation and disease · 2025Article
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Authors and funding
6 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Insulin resistance(IR) and inflammation have been regarded as common potential mechanisms in coronary heart disease (CHD) and non-alcoholic fatty liver disease (NAFLD). Triglyceride-glucose (TyG) index is a novel biomarker of insulin resistance, System immune-inflammation index(SII) and Systemic inflammation response index(SIRI) are novel biomarkers of inflammation, these biomarkers have not been studied in CHD with NAFLD patients. This study investigated the correlation between the TyG index, SII index, and SIRI index and CHD risk among NAFLD patients. Methods: This cross-sectional study included 407 patients with NAFLD in the Department of Cardiology, The Second Hospital of Shanxi Medical University. Of these, 250 patients with CHD were enrolled in the NAFLD+CHD group and 157 patients without CHD were enrolled as NAFLD control. To balance covariates between groups, 144 patients were selected from each group in a 1:1 ratio based on propensity score matching (PSM). Potential influences were screened using Lasso regression analysis. Univariate and multivariate logistic regression analyses and the Least Absolute Shrinkage and Selection Operator (LASSO) regression were used to assess independent risk and protective factors for CHD. Construction of nomogram using independent risk factors screened by machine learning. The receiver operating characteristic(ROC) curve was used to assess the ability of these independent risk factors to predict coronary heart disease. The relationship between the Gensini score and independent risk factors was reflected using the Sankey diagram. Results: The LASSO logistic regression analysis and Logistic regression analyses suggest that TyG index (OR, 2.193; 95% CI, 1.242-3.873; Conclusion: TyG index, SII index, and SIRI index are all independent risk factors for CHD in patients with NAFLD and are strongly associated with prediction and the severity of CHD.
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