Evidence map›Paper›PMID 38260251›Full record

ArticlebioRxiv : the preprint server for biology2024

Substrate recognition mechanism of the endoplasmic reticulum-associated ubiquitin ligase Doa10.

Kevin Wu, Samuel Itskanov, Diane L Lynch, Yuanyuan Chen, Aasha Turner, James C Gumbart, Eunyong Park

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Kevin WuDepartment of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
Samuel ItskanovBiophysics Graduate Program, University of California, Berkeley, CA 94720, USA.
Diane L LynchSchool of Physics and School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Yuanyuan ChenDepartment of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
Aasha TurnerDepartment of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
James C GumbartSchool of Physics and School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Eunyong ParkDepartment of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
QB3 · USGeorgia Institute of Technology · USUniversity of California, Berkeley · US

Funding

Dynamic characterization of outer-membrane-protein biogenesis by the BAM and TAM complexesR01GM123169 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI GUMBART, JAMES C. · 2017 to 2021
$1.4M
NIGMS NIH HHS R01 GM123169
6 · The paper itself

Abstract

Doa10 (MARCH6 in metazoans) is a large polytopic membrane-embedded E3 ubiquitin ligase in the endoplasmic reticulum (ER) that plays an important role in quality control of cytosolic and ER proteins. Although Doa10 is highly conserved across eukaryotes, it is not understood how Doa10 recognizes its substrates. Here, we defined the substrate recognition mechanism of Doa10 by structural and functional analyses on

Identifiers

PMID38260251
PMCPMC10802466
OpenAlexW4390700547

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.