Evidence map›Paper›PMID 38260399›Full record

ArticlebioRxiv : the preprint server for biology2024

Behavioral screening of conserved RNA-binding proteins reveals CEY-1/YBX RNA-binding protein dysfunction leads to impairments in memory and cognition.

Ashley N Hayden, Katie L Brandel, Paul R Merlau, Priyadharshini Vijayakumar, Emily J Leptich, Edward W Pietryk, Elizabeth S Gaytan, Connie W Ni, Hsiao-Tuan Chao, Jill A Rosenfeld and 1 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Ashley N HaydenDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0003-2836-7624
Katie L BrandelDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0002-2269-7166
Paul R MerlauCenter for Precision Environmental Health, Baylor College of Medicine, Houston, TX, 77030.
Priyadharshini VijayakumarCenter for Precision Environmental Health, Baylor College of Medicine, Houston, TX, 77030.
Emily J LeptichDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030.
Edward W PietrykCenter for Precision Environmental Health, Baylor College of Medicine, Houston, TX, 77030.ORCID 0000-0003-1563-0219
Elizabeth S GaytanCenter for Precision Environmental Health, Baylor College of Medicine, Houston, TX, 77030.
Connie W NiCenter for Precision Environmental Health, Baylor College of Medicine, Houston, TX, 77030.
Hsiao-Tuan ChaoDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0002-2854-5470
Jill A RosenfeldDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030.ORCID 0000-0001-5664-7987
Rachel N AreyCenter for Precision Environmental Health, Baylor College of Medicine, Houston, TX, 77030.ORCID 0000-0001-9941-3945
Baylor College of Medicine · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Uncovering brain-wide molecular determinants of individual memory performance across lifespanDP2NS132372 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI AREY, RACHEL NICOLE · 2022 to 2025
$2.4M
Presynaptic RNA binding protein regulation of learning and memory in C. elegansF31NS129312 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI HAYDEN, ASHLEY · 2022 to 2024
$122k
NIH HHS P40 OD010440NINDS NIH HHS DP2 NS132372NINDS NIH HHS F31 NS129312Wellcome Trust
6 · The paper itself

Abstract

RNA-binding proteins (RBPs) regulate translation and plasticity which are required for memory. RBP dysfunction has been linked to a range of neurological disorders where cognitive impairments are a key symptom. However, of the 2,000 RBPs in the human genome, many are uncharacterized with regards to neurological phenotypes. To address this, we used the model organism

Indexed as

associative memoryC eleganscopy number losseshumanizationlearningrare variantsRNA binding proteins

Identifiers

PMID38260399
PMCPMC10802296
OpenAlexW4390689419

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.