Evidence map›Paper›PMID 38260421›Full record

ArticlebioRxiv : the preprint server for biology2024

Neurotrophic factor MANF regulates autophagy and lysosome function to promote proteostasis in

Shane K B Taylor, Jessica H Hartman, Bhagwati P Gupta

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Shane K B TaylorDepartment of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada.ORCID 0000-0003-4904-4314
Jessica H HartmanDepartment of Biochemistry & Molecular Biology and Department of Regenerative Medicine & Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USA.
Bhagwati P GuptaDepartment of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada.ORCID 0000-0001-8572-7054
McMaster University · CAMedical University of South Carolina · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Exercise, MANF, and Chemical-Induced NeurodegenerationR00ES029552 · NIEHS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI HARTMAN, JESSICA HELENE · 2021 to 2023
$751k
NIEHS NIH HHS R00 ES029552NIH HHS P40 OD010440
6 · The paper itself

Abstract

The conserved mesencephalic astrocyte-derived neurotrophic factor (MANF) protects dopaminergic neurons but also functions in several other tissues. Previously, we showed that

Indexed as

agingautophagyC. elegansdopaminergic neuronER stressER-UPRlifespanlongevitylysosomeMANFMANF-1proteostasisUnfolded protein response

Identifiers

PMID38260421
PMCPMC10802257
OpenAlexW4385487817

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.