ArticlebioRxiv : the preprint server for biology2025
Loss of essential outer membrane functions causes drug hypersensitization in
Efrat Hamami, Wenwen Huo, Katherine Neal, Isabelle Neisewander, Edward Geisinger, Ralph R Isberg
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 3 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
6 authors at 2 institutions in 1 country.
Efrat HamamiDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, 150 Harrison Ave., Boston, MA 02111, USA.
Wenwen HuoDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, 150 Harrison Ave., Boston, MA 02111, USA.
Katherine NealDepartment of Biochemistry, Curry College, Milton, MA, USA.
Isabelle NeisewanderDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, 150 Harrison Ave., Boston, MA 02111, USA.
Edward GeisingerDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, 150 Harrison Ave., Boston, MA 02111, USA.
Ralph R IsbergDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, 150 Harrison Ave., Boston, MA 02111, USA.ORCID 0000-0002-8330-3554 Tufts University · USCurry College · US
Funding
Innovative technologies to transform antibiotic discovery. Project 4 Infection site-specific amplification of antimicrobial conjugatesU19AI142780 · NIAID · BROAD INSTITUTE, INC. · PI BLAINEY, PAUL CLARK · 2019 to 2023
$33.9MPredicting the emergence of antibiotic resistance through multi-omics approaches and Immune System-surveillanU01AI124302 · NIAID · BOSTON COLLEGE · PI BENTO, JOSE, COOPER, VAUGHN · 2016 to 2020
$10.2MDrug resistance enablers and their role in antibiotic treatment failureU19AI158076 · NIAID · BROAD INSTITUTE, INC. · PI COOPER, VAUGHN, ISBERG, RALPH R. · 2022 to 2025
$10.0MIdentification of the Achilles’ heel in Acinetobacter fluoroquinolone-resistant mutantsR21AI128328 · NIAID · TUFTS UNIVERSITY BOSTON · PI ISBERG, RALPH R. · 2017 to 2018
$454kNIAID NIH HHS R21 AI128328NIAID NIH HHS U01 AI124302NIAID NIH HHS U19 AI142780NIAID NIH HHS U19 AI158076
6 · The paper itselfAbstract
Elevated expression of Resistance-Nodulation-Cell Division (RND) drug transporters is commonly observed in clinical isolates of
Identifiers
PMID38260615
PMCPMC10802289
OpenAlexW4390649732
What Socratic holds
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