Evidence map›Paper›PMID 38260622›Full record

ArticlebioRxiv : the preprint server for biology2025

Histone H2A.Z Deacetylation and Dedifferentiation in Infarcted/Tip60-depleted Cardiomyocytes.

Xinrui Wang, Katherine Kulik, Tina C Wan, John W Lough, John A Auchampach

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Xinrui WangDepartment of Pharmacology and Toxicology.
Katherine KulikDepartment of Cell Biology Neurobiology and Anatomy.
Tina C WanDepartment of Pharmacology and Toxicology.
John W LoughDepartment of Cell Biology Neurobiology and Anatomy.
John A AuchampachDepartment of Pharmacology and Toxicology.
Medical College of Wisconsin · US

Funding

Tip60, Ischemic Heart Disease and RegenerationR01HL131788 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI AUCHAMPACH, JOHN A, LOUGH, JOHN W · 2017 to 2020
$2.0M
Adenosine Signaling During Post-Infarction Remodeling and Heart FailureR01HL133589 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI AUCHAMPACH, JOHN A · 2017 to 2020
$1.7M
VisualSonics Vevo 3100 High-Frequency Ultrasound Imaging SystemS10OD025038 · OD · MEDICAL COLLEGE OF WISCONSIN · PI AUCHAMPACH, JOHN A · 2019 to 2019
$302k
NHLBI NIH HHS R01 HL131788NHLBI NIH HHS R01 HL133589NIH HHS S10 OD025038
6 · The paper itself

Abstract

Myocardial infarction (MI) results in the loss of billions of cardiomyocytes (CMs), resulting in cardiac dysfunction. To re-muscularize injured myocardium, new CMs must be generated via renewed proliferation of surviving CMs. Approaches to induce proliferation of CMs after injury have been insufficient. Toward this end we are targeting the acetyltransferase Tip60, encoded by the

Indexed as

CardiomyocyteCUT&TagDedifferentiationHistone H2A.ZacK4/K7RNAseqTip60

Identifiers

PMID38260622
PMCPMC10802610
OpenAlexW4390839236

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.