Evidence map›Paper›PMID 38263841›Full record

ArticleThe British journal of radiology2024

Using intravoxel incoherent motion imaging to evaluate uric acid-induced renal injury and efficacy after treatment.

Zhong-Yuan Cheng, Shang-Ao Gong, Ping-Kang Chen, Zong-Chao Yu, Chen Qiu, Ji-Xin Lin, Jia-Bin Mo, Long Qian, You-Zhen Feng, Xiang-Ran Cai

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The British journal of radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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  5. Impact ofFrontiers in pharmacology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Zhong-Yuan ChengMedical Imaging Department, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, China.
Shang-Ao GongMedical Imaging Department, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, China.
Ping-Kang ChenMedical Imaging Department, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, China.
Zong-Chao YuNephrology Department, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, China.
Chen QiuNew Medicine Department, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, China.
Ji-Xin LinTraditional Chinese Medicine Department, Lecong Hospital of Shunde, Foshan 528315, China.
Jia-Bin MoDepartment of Radiology, The Affiliated Shunde Hospital of Jinan University, Foshan, Guangdong Province 528306, China.
Long QianDepartment of Biomedical Engineering, College of Engineering, Peking University, Beijing 100091, China.
You-Zhen FengMedical Imaging Department, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, China.
Xiang-Ran CaiMedical Imaging Department, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, China.ORCID 0000-0003-4010-7577
First Affiliated Hospital of Jinan University · CNFoshan Hospital of TCM · CNJinan University · CNPeking University · CN

Funding

Administration of Traditional Chinese Medicine of Guangdong Province 20221110Medical Scientific Research Foundation of Guangdong Province A2022337National Natural Science Foundation of China 82202284Science and Technology Projects in Foshan 2220001003957Science and Technology Projects in Guangzhou 202201011089
6 · The paper itself

Abstract

objectivesTo validate the feasibility of intravoxel incoherent motion imaging (IVIM) for monitoring renal injury and uric acid-lowering efficacy in a rat model of hyperuricaemia.

methodsA total of 92 rats were analysed and categorized into 4 groups: control (CON), hyperuricaemia (HUA), allopurinol intervention (ALL), and combined intervention (COM). Eight rats were randomly selected from each group and underwent IVIM scanning on days 0, 1, 3, 5, 7, and 9. Quantitative magnetic resonance values (D, D*, and f values) measured from the different renal anatomical regions. Quantitative histopathological analysis was performed to assess renal tubular injury using neutrophil gelatinase-associated lipocalin (NGAL), and renal fibrosis using alpha-smooth-muscle-actin (α-SMA). Pearson's correlation analysis was used to determine the correlation between IVIM-derived parameters and the expression of NGAL and α-SMA.

resultsThe D values of the HUA, ALL, and COM groups generally showed a downward trend over time, and this fluctuation was most significant in the HUA group. The D values showed significant intergroup differences at each point, whereas only a few discrepancies were found in the D* and f values. In addition, the renal D value was negatively correlated with the positive staining rates for NGAL and α-SMA (P < .05), except for the lack of correlation between Dos and α-SMA (P > .05).

conclusionIVIM could be a noninvasive and potential assessment modality for the evaluation of renal injury induced by hyperuricaemia and its prognostic efficacy. ADVANCES IN KNOWLEDGE: IVIM could be a surrogate manner in monitoring renal damage induced by hyperuricaemia and its treatment evaluation.

Indexed as

HyperuricemiaAnimalsDiagnostic ImagingKidneyLipocalin-2RatsUric AcidLipocalin-2Uric Acidhyperuricaemiaintravoxel incoherent motionkidney injuryuric acid lowering therapy

Identifiers

PMID38263841
PMCPMC11027338
OpenAlexW4390772071

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.