Evidence map›Paper›PMID 38264142›Full record

ArticleSleep advances : a journal of the Sleep Research Society2024

Hydrogen-rich water improves sleep consolidation and enhances forebrain neuronal activation in mice.

Scott M Vincent, Melika Madani, Dante Dikeman, Kyle Golden, Naomi Crocker, Cameron Jackson, Sam P Wimmer, Mary Dover, Alexis Tucker, Cristina A Ghiani and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep advances : a journal of the Sleep Research Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Trial
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Scott M VincentDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-6403-0546
Melika MadaniDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.
Dante DikemanDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.
Kyle GoldenDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.
Naomi CrockerDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.
Cameron JacksonDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.
Sam P WimmerDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.
Mary DoverDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.
Alexis TuckerDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.
Cristina A GhianiDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-9867-6185
Christopher S ColwellDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Tyler W LeBaronDepartment of Kinesiology and Outdoor Recreation, Southern Utah University, Cedar City, UT, USA.
Alex TarnavaNatural Wellness Now Health Products Inc, Maple ridge, BC, Canada.
Ketema N PaulDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.

Funding

UCLA IDDRC: Translational CoreP50HD103557 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Peyman Golshani, SUMA JACOB · 2020 to 2026
$9.6M
The impact of sex chromosomes on the ability to recover from sleep lossR01NS078410 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PAUL, KETEMA N · 2012 to 2025
$3.7M
NICHD NIH HHS P50 HD103557NINDS NIH HHS R01 NS078410
6 · The paper itself

Abstract

Study Objectives: Sleep loss contributes to various health issues and impairs neurological function. Molecular hydrogen has recently gained popularity as a nontoxic ergogenic and health promoter. The effect of molecular hydrogen on sleep and sleep-related neural systems remains unexplored. This study investigates the impact of hydrogen-rich water (HRW) on sleep behavior and neuronal activation in sleep-deprived mice. Methods: Adult C57BL/6J mice were implanted with electroencephalography (EEG) and electromyography (EMG) recording electrodes and given HRW (0.7-1.4 mM) or regular water for 7 days ad libitum. Sleep-wake cycles were recorded under baseline conditions and after acute sleep loss. Neuronal activation in sleep- and wake-related regions was assessed using cFos immunostaining. Results: HRW increased sleep consolidation in undisturbed mice and increased non-rapid-eye movement and rapid-eye-movement sleep amount in sleep-deprived mice. HRW also decreased the average amount of time for mice to fall asleep after light onset. Neuronal activation in the lateral septum, medial septum, ventrolateral preoptic area, and median preoptic area was significantly altered in all mice treated with HRW. Conclusions: HRW improves sleep consolidation and increases neuronal activation in sleep-related brain regions. It may serve as a simple, effective treatment to improve recovery after sleep loss.

Indexed as

cFosdeprivationfragmentationHRWhydrogen-rich waterhypnoticinsomnialatencyseptual nucleisleep

Identifiers

PMID38264142
PMCPMC10803172

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.